Since the identification of dystrophin as the causative factor in Duchenne muscular
dystrophy, an increasing amount of information on the molecular basis of muscular …

Zebrafish reproduce in large quantities, grow rapidly, and are transparent early in
development. For these reasons, zebrafish have been used extensively to model vertebrate …

Duchenne muscular dystrophy was described in the medical literature in the early 1850s but
the molecular basis of the disease was not determined until the late 1980s. The cloning of …

The rat L6 skeletal muscle cell line was used to study expression of the dystrophin-
containing glycoprotein complex and its interaction with the integrin system involved in the …

Recently, mutations in the genes encoding several of the dystrophin-associated proteins
have been identified that produce phenotypes ranging from severe Duchenne-like …

Objective: To determine whether the concentrations of the neuronal marker N-
acetylaspartate (NAA) and the choline-containing metabolites (Cho) are altered in the …

Among 14 limb-girdle muscular dystrophy genes that have been mapped, 10 (three
autosomal dominant and seven autosomal recessive) have so far had their product …

Limb-girdle muscular dystrophy (LGMD) constitutes a clinically and genetically
heterogeneous group of myogenic disorders with a limb-girdle distribution of weakness. One …

Dystrophin is the scaffold of a protein complex, disrupted in inherited muscular dystrophies.
At the last 3′ terminus of the gene, a protein domain is encoded, where syntrophins are …

The involvement of the sarcoglycan complex in the pathogenesis of muscular dystrophy is
becoming increasingly clear. Sarcoglycan gene mutations lead to four forms of autosomal …