Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …

Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain
neurons in the CNS during development and control plasticity in the adult CNS. They appear …

Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …

Background The extracellular matrix (ECM) of the brain is rich in glycosaminoglycans such
as chondroitin sulfate (CS) and hyaluronan. These glycosaminoglycans are organized into …

Huntington's disease is associated with a reactive microglial response and consequent
inflammation. To address the role of these cells in disease pathogenesis, we depleted …

Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central
nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different …

Brain damage due to stroke or traumatic brain injury (TBI), both leading causes of serious
long-term disability, often leads to the development of epilepsy. Patients who develop post …

GABAergic interneurons of the parvalbumin-positive fast-spiking basket cells subtype (PV
INs) are important regulators of cortical network excitability and of gamma oscillations …

Chondroitin sulfate (CS) is a glycosaminoglycan with a broad range of applications being a
popular dietary supplement for osteoarthritis. Usually, CS is extracted from animal sources …

Perineuronal nets (PNNs) are aggregations of extracellular matrix molecules that are critical
for plasticity. Their altered development or changes during adulthood appear to contribute to …