Objectives The lack of systematic evidence on neuroimaging findings in motor neuron
diseases (MND) hampers the diagnostic utility of magnetic resonance imaging (MRI). Thus …

Introduction While the imaging signatures of frontotemporal lobar degeneration (FTLD)
phenotypes and genotypes are well-characterized based on group-level descriptive …

Background: Magnetic resonance spectroscopy (MRS) in amyotrophic lateral sclerosis
(ALS) has been overwhelmingly applied to motor regions to date and our understanding of …

A summit held March 2023 in Scottsdale, Arizona (USA) focused on the intronic
hexanucleotide expansion in the C9ORF72 gene and its relevance in frontotemporal …

Background The characterisation of presymptomatic disease-burden patterns in
asymptomatic mutation carriers has a dual academic and clinical relevance. The …

Introduction Pseudobulbar affect (PBA) is a distressing symptom of a multitude of
neurological conditions affecting patients with a rage of neuroinflammatory, neurovascular …

Background The clinical phenotypes of frontotemporal dementia (FTD) are defined by
distinctive clinical features and associated with unique cortical atrophy patterns. Clinical …

Imaging studies of FTD typically present group-level statistics between large cohorts of
genetically, molecularly or clinically stratified patients. Group-level statistics are …

Introduction Functional connectivity (FC)—which reflects relationships between neural
activity in different brain regions—has been used to explore the functional architecture of the …

Background Frontotemporal dementia (FTD) phenotypes are classically associated with
distinctive cortical atrophy patterns and regional hypometabolism. However, the spectrum of …