[HTML][HTML] C9orf72 repeat length might influence clinical sub-phenotypes in dementia patients
Background C9orf72 repeat expansions have been observed in a wide variety of
neurodegenerative disorders. The cut-off between normal and pathogenic alleles is not well …
neurodegenerative disorders. The cut-off between normal and pathogenic alleles is not well …
Distinct patterns of progressive gray and white matter degeneration in amyotrophic lateral sclerosis
Progressive cerebral degeneration in amyotrophic lateral sclerosis (ALS) remains poorly
understood. Here, three‐dimensional (3D) texture analysis was used to study longitudinal …
understood. Here, three‐dimensional (3D) texture analysis was used to study longitudinal …
Language deficits in primary lateral sclerosis: cortical atrophy, white matter degeneration and functional disconnection between cerebral regions
EL Tan, M Tahedl, J Lope, JC Hengeveld… - Journal of …, 2024 - Springer
Background Primary lateral sclerosis (PLS) is traditionally regarded as a pure upper motor
neuron disorder, but recent cases series have highlighted cognitive deficits in executive and …
neuron disorder, but recent cases series have highlighted cognitive deficits in executive and …
Resting‐state fMRI functional connectome of C9orf72 mutation status
Objective The resting‐state functional connectome has not been extensively investigated in
amyotrophic lateral sclerosis (ALS) spectrum disease, in particular in relationship with …
amyotrophic lateral sclerosis (ALS) spectrum disease, in particular in relationship with …
[HTML][HTML] C9ORF72 hexanucleotide repeat expansion: From ALS and FTD to a broader pathogenic role?
The major gene underlying monogenic forms of amyotrophic lateral sclerosis (ALS) and
fronto-temporal dementia (FTD) is C9ORF72. The causative mutation in C9ORF72 is an …
fronto-temporal dementia (FTD) is C9ORF72. The causative mutation in C9ORF72 is an …
The involvement of language‐associated networks, tracts, and cortical regions in frontotemporal dementia and amyotrophic lateral sclerosis: Structural and functional …
M Tahedl, EL Tan, RH Chipika, J Lope… - Brain and …, 2023 - Wiley Online Library
Background Language deficits are cardinal manifestations of some frontotemporal dementia
(FTD) phenotypes and also increasingly recognized in sporadic and familial amyotrophic …
(FTD) phenotypes and also increasingly recognized in sporadic and familial amyotrophic …
Structural and Functional Brain Network Connectivity at Different King's Stages in Patients With Amyotrophic Lateral Sclerosis
EG Spinelli, A Ghirelli, S Basaia, E Canu… - Neurology, 2024 - AAN Enterprises
Background and Objectives There is currently no validated disease-stage biomarker for
amyotrophic lateral sclerosis (ALS). The identification of quantitative and reproducible …
amyotrophic lateral sclerosis (ALS). The identification of quantitative and reproducible …
[HTML][HTML] Structural and microstructural neuroimaging signature of C9orf72-associated ALS: A multiparametric MRI study
M Wiesenfarth, HJ Huppertz, J Dorst, D Lulé… - NeuroImage: Clinical, 2023 - Elsevier
Background ALS patients with hexanucleotide expansion in C9orf72 are characterized by a
specific clinical phenotype, including more aggressive disease course and cognitive …
specific clinical phenotype, including more aggressive disease course and cognitive …