[HTML][HTML] Natural killer cells in antitumour adoptive cell immunotherapy

TJ Laskowski, A Biederstädt, K Rezvani - Nature Reviews Cancer, 2022 - nature.com
Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with
intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing …

Roles of natural killer cells in immunity to cancer, and applications to immunotherapy

NK Wolf, DU Kissiov, DH Raulet - Nature Reviews Immunology, 2023 - nature.com
Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion

S Jhunjhunwala, C Hammer, L Delamarre - Nature Reviews Cancer, 2021 - nature.com
Immune checkpoint blockade, which blocks inhibitory signals of T cell activation, has shown
tremendous success in treating cancer, although success still remains limited to a fraction of …

[HTML][HTML] NK cell-based cancer immunotherapy: from basic biology to clinical development

S Liu, V Galat, Y Galat4, YKA Lee… - Journal of hematology & …, 2021 - Springer
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …

Exploring the NK cell platform for cancer immunotherapy

JA Myers, JS Miller - Nature reviews Clinical oncology, 2021 - nature.com
Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that are
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …

[HTML][HTML] Natural killer cell homing and trafficking in tissues and tumors: from biology to application

GH Ran, YQ Lin, L Tian, T Zhang, DM Yan… - Signal transduction and …, 2022 - nature.com
Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

Tumor-infiltrating natural killer cells

B Cózar, M Greppi, S Carpentier, E Narni-Mancinelli… - Cancer discovery, 2021 - AACR
Because of their potent antitumor activity and their proinflammatory role, natural killer (NK)
cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells …

Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders

NA Maskalenko, D Zhigarev… - Nature reviews Drug …, 2022 - nature.com
Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and
viral infections. They are 'first responders' that can spontaneously recognize abnormal cells …

NK cells for cancer immunotherapy

N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

Innate lymphoid cells and cancer

N Jacquelot, C Seillet, E Vivier, GT Belz - Nature Immunology, 2022 - nature.com
The innate lymphoid cell (ILC) family is composed of natural killer (NK) cells, ILC1, ILC2 and
ILC3, which participate in immune responses to virus, bacteria, parasites and transformed …