The role of inflammation in the pathogenesis of osteoarthritis

YY Chow, KY Chin - Mediators of inflammation, 2020 - Wiley Online Library
A joint is the point of connection between two bones in our body. Inflammation of the joint
leads to several diseases, including osteoarthritis, which is the concern of this review …

[HTML][HTML] State of the art: the immunomodulatory role of MSCs for osteoarthritis

DG Kwon, MK Kim, YS Jeon, YC Nam, JS Park… - International journal of …, 2022 - mdpi.com
Osteoarthritis (OA) has generally been introduced as a degenerative disease; however, it
has recently been understood as a low-grade chronic inflammatory process that could …

[PDF][PDF] Protective effect of resveratrol on knee osteoarthritis and its molecular mechanisms: a recent review in preclinical and clinical trials

S Yang, M Sun, X Zhang - Frontiers in Pharmacology, 2022 - frontiersin.org
Osteoarthritis (OA) is one of the progressing chronic joint associated with by many complex
factors such as age, obesity, and trauma. Knee osteoarthritis (KOA) is the most common type …

[HTML][HTML] Spermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis

Z Chen, CX Lin, B Song, CC Li, JX Qiu, SX Li… - Cell death & …, 2020 - nature.com
Spermidine has been known to inhibit the production of pro-inflammatory cytokines.
However, there are no reports about anti-inflammatory effects of spermidine on osteoarthritis …

[HTML][HTML] Osteoarthritis year in review 2018: biomarkers (biochemical markers)

FS Hosnijeh, SM Bierma-Zeinstra… - Osteoarthritis and …, 2019 - Elsevier
Objective The aim of this narrative review is to summarize important findings from
biochemical marker studies relevant to osteoarthritis (OA) in the context of new discoveries …

[HTML][HTML] Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development

O Malaise, Y Tachikart, M Constantinides… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Tissue accumulation of p16 INK4a-positive senescent cells is associated with age-related
disorders, such as osteoarthritis (OA). These cell-cycle arrested cells affect tissue function …

Butyrate Inhibits Osteoclast Activity In Vitro and Regulates Systemic Inflammation and Bone Healing in a Murine Osteotomy Model Compared to Antibiotic‐Treated …

A Wallimann, W Magrath, B Pugliese… - Mediators of …, 2021 - Wiley Online Library
Short‐chain fatty acids (SCFAs) produced by the gut microbiota have previously been
demonstrated to play a role in numerous chronic inflammatory diseases and to be key …

Systemic inflammatory markers in neck pain: A systematic review with meta‐analysis

SF Farrell, RMJ de Zoete, PJ Cabot… - European Journal of …, 2020 - Wiley Online Library
Abstract Background and Objective Mechanisms underpinning symptoms in non‐traumatic
neck pain (NTNP) and whiplash‐associated disorder (WAD) are not comprehensively …

Resveratrol supplementation reduces pain and inflammation in knee osteoarthritis patients treated with meloxicam: a randomized placebo-controlled study

BH Marouf, SA Hussain, ZS Ali… - Journal of medicinal …, 2018 - liebertpub.com
Resveratrol, a polyphenolic compound, is a powerful antioxidant with remarkable anti-
inflammatory properties. Inflammation and pain plays an important role in the pathogenesis …

[HTML][HTML] Natural compounds: potential therapeutics for the inhibition of cartilage matrix degradation in osteoarthritis

OS Ashruf, MY Ansari - Life, 2022 - mdpi.com
Osteoarthritis (OA) is the most common degenerative joint disease characterized by
enzymatic degradation of the cartilage extracellular matrix (ECM) causing joint pain and …