Metabolic anomalies contribute to tissue dysfunction. Current metabolism research spans
from organelles to populations, and new technologies can accommodate investigation …

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Over the past century, the notion that vitamin C can be used to treat cancer has generated
much controversy. However, new knowledge regarding the pharmacokinetic properties of …

Germline loss-of-function mutations of the VHL tumor suppressor gene cause von Hippel–
Lindau disease, which is associated with an increased risk of hemangioblastomas, clear cell …

Tumors reprogram pathways of nutrient acquisition and metabolism to meet the
bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed …

Next-generation sequencing has revealed that more than 50% of human cancers harbour
mutations in enzymes that are involved in chromatin organization. Tumour cells not only are …

Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the
second most common form of acute leukemia in children. Despite this, very little …

Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct
and indirect consequence of oncogenic mutations. A common feature of cancer cell …

Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …

Abstract Approximately 8% to 19% of patients with acute myeloid leukemia (AML) have
isocitrate dehydrogenase-2 (IDH2) mutations, which occur at active site arginine residues …