Cardiovascular diseases (CVDs), particularly heart failure, are major contributors to early
mortality globally. Heart failure poses a significant public health problem, with persistently …

Neurodegenerative diseases (NDs) are a set of progressive, chronic, and incurable
diseases characterized by the gradual loss of neurons, culminating in the decline of …

Namodenoson, an A3 adenosine receptor (A3AR) agonist, is currently being used in a
phase III trial in advanced liver cancer. We examined the anti-growth effect of namodenoson …

Adenosine receptors are largely distributed in our organism and are promising therapeutic
targets for the treatment of many pathologies. In this perspective, investigating the structural …

Adenine is one of the most ubiquitous heterocycles in life. In addition of being one of the four
nucleobases constituting DNA and RNA, adenine is also contained in many biological …

Purinergic signaling networks have emerged as central control mechanisms that regulate a
wide spectrum of physiological processes. They involve autocrine and paracrine systems …

Astrocytes, once considered passive support cells in the central nervous system, are now
recognized as dynamic contributors to neuronal processes. They play pivotal roles in …

Introduction and purpose: Parkinson's disease (PD) is the second most common
neurodegenerative disease, mainly characterized by motor impairment with symptoms …