StimulusResponsive Drug Delivery Nanoplatforms for Osteoarthritis Therapy

Q Jiang, S Zhang - Small, 2023 - Wiley Online Library
Osteoarthritis (OA) is one of the most prevalent agerelated degenerative diseases. With an
increasingly aging global population, greater numbers of OA patients are providing clear …

Harnessing Nanomedicine for Cartilage Repair: Design Considerations and Recent Advances in Biomaterials

H Zhou, Z Zhang, Y Mu, H Yao, Y Zhang, DA Wang - ACS nano, 2024 - ACS Publications
Cartilage injuries are escalating worldwide, particularly in aging society. Given its limited self-
healing ability, the repair and regeneration of damaged articular cartilage remain formidable …

Hyaluronic acid hydrogel containing resveratrol-loaded chitosan nanoparticles as an adjuvant in atopic dermatitis treatment

R Conte, I De Luca, A Valentino, P Cerruti… - Journal of Functional …, 2023 - mdpi.com
Atopic dermatitis (AD) is a common disease-causing skin inflammation, redness, and
irritation, which can eventually result in infection that drastically impacts patient quality of life …

Novel strategy of senescence elimination via toxicity-exempted kinome perturbations by nanoliposome-based thermosensitive hydrogel for osteoarthritis therapy

J Wan, Z He, Y Zhao, X Hao, J Cui, A Chen… - … Composites and Hybrid …, 2023 - Springer
Cellular senescence and the senescence-associated secretory phenotype (SASP) have
been implicated in osteoarthritis (OA). This study aims to determine whether multi-kinase …

Polylactic acid/poly (vinylpyrrolidone) co-electrospun fibrous membrane as a tunable quercetin delivery platform for diabetic wounds

F Di Cristo, A Valentino, I De Luca, G Peluso… - Pharmaceutics, 2023 - mdpi.com
Diabetic wound infections (DWI) represent one of the most costly and disruptive
complications in diabetic mellitus. The hyperglycemic state induces a persistent …

In-Situ thermoresponsive hydrogel containing resveratrol-loaded nanoparticles as a localized drug delivery platform for dry eye disease

I De Luca, F Di Cristo, R Conte, G Peluso, P Cerruti… - Antioxidants, 2023 - mdpi.com
Dry eye disease (DED) is a dynamic and complex disease that can cause significant
damage to the ocular surface and discomfort, compromising the patient's quality of life …

Regeneration of dentin-pulp complex: Effect of calcium-based materials on hDPSCs differentiation and gene expression

G Spagnuolo, I De Luca, F Iaculli, E Barbato, A Valletta… - Dental Materials, 2023 - Elsevier
Objective Dentin-pulp complex is object of interest in the regenerative endodontic field as
well as the natural function of human dental pulp stem cells (hDPSCs) that may differentiate …

Thermosensitive in situ gels for joint disorders: pharmaceutical considerations in intra-articular delivery

M Koland, A Narayanan Vadakkepushpakath, A John… - Gels, 2022 - mdpi.com
The intra-articular administration of conventional drug solutions or dispersions in joint
diseases such as osteoarthritis has a relatively short retention time and, therefore, limited …

In Vitro and Ex Vivo Evaluation of Mangifera indica L. Extract-Loaded Green Nanoparticles in Topical Emulsion against Oxidative Stress and Aging

ZU Khan, T Khan, A Mannan, A Ali, J Ni - Biomedicines, 2022 - mdpi.com
Although Mangifera indica L. extract (M-Ext) of the peel and kernel possesses potent
antioxidant and excellent antiaging qualities, the effects are only partially seen because of …

[HTML][HTML] Thermo-Responsive Hydrogel Containing Microfluidic Chitosan Nanoparticles Loaded with Opuntia ficus-indica Extract for Periodontitis Treatment

R Conte, A Valentino, I De Luca… - International Journal of …, 2024 - mdpi.com
Periodontitis is a chronic inflammatory disease resulting from the dysbiosis of periodontal
bacteria and the host's immune response, leading to tissue degradation and sustained …