Background The findings of randomised controlled trials (RCT), observational studies, and
meta-analyses vary regarding the effectiveness of prolonged β-lactam infusion. We aimed to …

Piperacillin–tazobactam is a β-lactam/β-lactamase inhibitor combination with a broad
spectrum of antibacterial activity that includes Gram-positive and-negative aerobic and …

Efficient treatment of chronic lung infections caused by Pseudomonas aeruginosa biofilms is
a great challenge because of drug tolerance and immune evasion issues. Here, we develop …

Piperacillin-tazobactam (PTZ) is one of the most common antibiotics administered to
hospitalized patients. Its broad activity against gram-negative, gram-positive, and anaerobic …

Subinhibitory concentrations (sub-MICs) of antibiotics, although not able to kill bacteria, can
modify their physico-chemical characteristics and the architecture of their outermost surface …

The treatment of infections in critically ill obese and morbidly obese patients is challenging
because of the combined physiological changes that result from obesity and critical illness …

The primary objectives of this analysis were to determine which pharmacokinetic model
most accurately describes the elimination pathways for piperacillin in the presence of …

Importance of the field: Piperacillin-tazobactam is a frequently prescribed intravenous
antibiotic for moderate to severe infections used in hospital settings because of its broad …

The objective of this study was to assess the achievement of pharmacokinetic/
pharmacodynamic (PK/PD) targets of meropenem (MEM) in critically-ill patients with …

Background The primary objective of this meta-analysis is aimed at determining whether β-
lactams prolonged infusion in patients with nosocomial pneumonia (NP) results in higher …