Hereditary cancer syndromes result from germline genetic alterations predisposing
individuals to higher lifetime cancer risk than the general population. Hereditary cancer …

Background Objections have been raised to performing risk-reducing salpingo-
oophorectomy (RRSO) to reduce disease incidence and mortality of women with BRCA …

Most of breast cancer cases are sporadic; however, 15–20% are associated with family
history, and some are inherited. Among those, deleterious mutations in BRCA1 and BRCA2 …

Background Women with a BRCA mutation have significantly elevated breast cancer risk,
which can be reduced by> 90% with bilateral prophylactic mastectomy (BPM). We sought to …

Background Carriers of deleterious mutations in breast cancer predisposition genes are
presented with critical choices regarding cancer risk management. Risk-reduction …

Purpose The aim of this study was to compare patient-reported outcomes (PROs) of
BRCA1/2 mutation carriers, either after bilateral prophylactic mastectomy (BPM) or during …

Providing women who have tested positive for a pathogenic variant in BRCA1 or BRCA 2
relevant information can help them to make informed decisions about managing their cancer …

For women with genetic risk of breast cancer, the addition of screening breast MRI to
mammography has become a standard. The order and interval of annual imaging can be …

There is limited information known about how women with pathogenic variants (PV) in
moderate penetrance genes make decisions to manage their increased risk of breast …

Objetivo Estudiar el perfil de las pacientes con cáncer de mama y mutación BRCA1 o
BRCA2. Material y métodos Se realizó un estudio retrospectivo entre 2010 y 2016 de 28 …