Abstract Vitamin B12 (cobalamin, Cbl) is required as a cofactor by two human enzymes, 5‐
methyltetrahydrofolate‐homocysteine methyltransferase (MTR) and methylmalonyl‐CoA …

ATP‐binding cassette (ABC) superfamily is one of the largest groups of primary active
transporters that could be found in all kingdoms of life from bacteria to humans. In humans …

Human ABC transporter ABCD1 transports very long-chain fatty acids from cytosol to
peroxisome for β-oxidation, dysfunction of which usually causes the X-linked …

Solute carrier (SLC) proteins represent the largest superfamily of transmembrane
transporters. While many of them play key biological roles, their systematic analysis has …

BacA is a mycobacterial ATP-binding cassette (ABC) transporter involved in the
translocation of water-soluble compounds across the lipid bilayer. Whole-cell-based assays …

A wide variety of organisms encode cobalamin-dependent enzymes catalyzing essential
metabolic reactions, but the cofactor cobalamin (vitamin B12) is only synthesized by a …

Acquired vitamin B12 (vB12) deficiency (vB12D) of newborns is relatively frequent as
compared with the incidence of inherited diseases included in newborn screening (NBS) of …

The ATP-binding cassette (ABC) transporters are one of the largest families of membrane-
bound proteins and exist in almost all living organisms from eubacteria to mammals. They …

ABCD4, which belongs to the ABC protein subfamily D, plays a role in the transport of
cobalamin from lysosomes to the cytosol by cooperating with ATP‐binding and ATP …

Background Methylmalonic acidemia (MMA) is a rare inborn error of propionate metabolism
caused by deficiency of the mitochondrial methylmalonyl-CoA mutase (MUT) enzyme. As …