Monocytes and macrophages in abdominal aortic aneurysm

J Raffort, F Lareyre, M Clément… - Nature Reviews …, 2017 - nature.com
Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade

J Vandooren, PE Van den Steen… - Critical reviews in …, 2013 - Taylor & Francis
Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1· 9 million people

AD Shah, C Langenberg, E Rapsomaniki… - The lancet Diabetes & …, 2015 - thelancet.com
Background The contemporary associations of type 2 diabetes with a wide range of incident
cardiovascular diseases have not been compared. We aimed to study associations between …

Single-cell RNA sequencing reveals the cellular heterogeneity of aneurysmal infrarenal abdominal aorta

G Zhao, H Lu, Z Chang, Y Zhao, T Zhu… - Cardiovascular …, 2021 - academic.oup.com
Aims The artery contains numerous cell types which contribute to multiple vascular
diseases. However, the heterogeneity and cellular responses of these vascular cells during …

Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms

FM Davis, LC Tsoi, WJ Melvin, A DenDekker… - Journal of Experimental …, 2021 - rupress.org
Abdominal aortic aneurysms (AAAs) are a life-threatening disease for which there is a lack
of effective therapy preventing aortic rupture. During AAA formation, pathological vascular …

Risk profiles for aortic dissection and ruptured or surgically treated aneurysms: a prospective cohort study

M Landenhed, G Engström, A Gottsäter… - Journal of the …, 2015 - Am Heart Assoc
Background Community screening to guide preventive interventions for acute aortic disease
has been recommended in high‐risk individuals. We sought to prospectively assess risk …

Association between advanced age and vascular disease in different arterial territories: a population database of over 3.6 million subjects

N Savji, CB Rockman, AH Skolnick, Y Guo… - Journal of the American …, 2013 - jacc.org
Objectives: This study sought to determine the relationship between vascular disease in
different arterial territories and advanced age. Background: Vascular disease in the …

Age-associated sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm

HZ Chen, F Wang, P Gao, JF Pei, Y Liu, TT Xu… - Circulation …, 2016 - Am Heart Assoc
Rationale: Uncontrolled growth of abdominal aortic aneurysms (AAAs) is a life-threatening
vascular disease without an effective pharmaceutical treatment. AAA incidence dramatically …

Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases

P Song, T Ramprasath, H Wang, MH Zou - Cellular and Molecular Life …, 2017 - Springer
Kynurenine pathway (KP) is the primary path of tryptophan (Trp) catabolism in most
mammalian cells. The KP generates several bioactive catabolites, such as kynurenine (Kyn) …

The mechanism and therapy of aortic aneurysms

J Gao, H Cao, G Hu, Y Wu, Y Xu, H Cui, HS Lu… - Signal transduction and …, 2023 - nature.com
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …