Monocytes and macrophages in abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade
J Vandooren, PE Van den Steen… - Critical reviews in …, 2013 - Taylor & Francis
Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …
Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1· 9 million people
AD Shah, C Langenberg, E Rapsomaniki… - The lancet Diabetes & …, 2015 - thelancet.com
Background The contemporary associations of type 2 diabetes with a wide range of incident
cardiovascular diseases have not been compared. We aimed to study associations between …
cardiovascular diseases have not been compared. We aimed to study associations between …
Single-cell RNA sequencing reveals the cellular heterogeneity of aneurysmal infrarenal abdominal aorta
Aims The artery contains numerous cell types which contribute to multiple vascular
diseases. However, the heterogeneity and cellular responses of these vascular cells during …
diseases. However, the heterogeneity and cellular responses of these vascular cells during …
Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms
FM Davis, LC Tsoi, WJ Melvin, A DenDekker… - Journal of Experimental …, 2021 - rupress.org
Abdominal aortic aneurysms (AAAs) are a life-threatening disease for which there is a lack
of effective therapy preventing aortic rupture. During AAA formation, pathological vascular …
of effective therapy preventing aortic rupture. During AAA formation, pathological vascular …
Risk profiles for aortic dissection and ruptured or surgically treated aneurysms: a prospective cohort study
M Landenhed, G Engström, A Gottsäter… - Journal of the …, 2015 - Am Heart Assoc
Background Community screening to guide preventive interventions for acute aortic disease
has been recommended in high‐risk individuals. We sought to prospectively assess risk …
has been recommended in high‐risk individuals. We sought to prospectively assess risk …
Association between advanced age and vascular disease in different arterial territories: a population database of over 3.6 million subjects
N Savji, CB Rockman, AH Skolnick, Y Guo… - Journal of the American …, 2013 - jacc.org
Objectives: This study sought to determine the relationship between vascular disease in
different arterial territories and advanced age. Background: Vascular disease in the …
different arterial territories and advanced age. Background: Vascular disease in the …
Age-associated sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm
HZ Chen, F Wang, P Gao, JF Pei, Y Liu, TT Xu… - Circulation …, 2016 - Am Heart Assoc
Rationale: Uncontrolled growth of abdominal aortic aneurysms (AAAs) is a life-threatening
vascular disease without an effective pharmaceutical treatment. AAA incidence dramatically …
vascular disease without an effective pharmaceutical treatment. AAA incidence dramatically …
Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases
Kynurenine pathway (KP) is the primary path of tryptophan (Trp) catabolism in most
mammalian cells. The KP generates several bioactive catabolites, such as kynurenine (Kyn) …
mammalian cells. The KP generates several bioactive catabolites, such as kynurenine (Kyn) …
The mechanism and therapy of aortic aneurysms
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …