A critical aspect of evolution is the layer of developmental physiology that operates between
the genotype and the anatomical phenotype. While much work has addressed the evolution …

In wound healing, individual cells' behaviors coordinate movement toward the wound center
to restore small or large barrier defects. The migration of epithelial cells as a continuous …

Many aspects of health and disease are modeled using the abstraction of a" pathway"—a
set of protein or other subcellular activities with specified functional linkages between them …

Using the formal framework of the Free Energy Principle, we show how generic
thermodynamic requirements on bidirectional information exchange between a system and …

Morphoceuticals are a new class of interventions that target the setpoints of anatomical
homeostasis for efficient, modular control of growth and form. Here, we focus on a subclass …

Complex living agents consist of cells, which are themselves competent sub-agents
navigating physiological and metabolic spaces. Behaviour science, evolutionary …

The history of direct cell-cell communication has evolved in several small steps. First
discovered in the 1930s in invertebrate nervous systems, it was thought at first to be an …

The connective tissue or fascia plays key roles in maintaining bodily function and health.
The fascia is made up of solid and fluid portions, which interpenetrate and interact with each …

Spatiotemporal patterns of cellular resting potential regulate several aspects of
development. One key aspect of the bioelectric code is that transcriptional and …

A medically important feature of several types of tumors is their ability to “decide” between
staying at a primary site in the body or leaving it and forming metastases. The present …