Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain
barrier and systemic adverse effects. Intranasal administration offers a direct route to the …

Dementias, including the type associated with Alzheimer's disease (AD), are on the rise
worldwide. Similarly, type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic …

Pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, is
known to have anti-inflammatory and anti-oxidant effects on the brain, and its clinical …

Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder
with no effective therapeutic drugs currently. The complicated pathophysiology of AD is not …

Background: The continuously increasing association of Alzheimer's disease (AD) with
increased mortality rates indicates an unmet medical need and the critical need for …

Dopamine regulates several functions, such as voluntary movements, spatial memory,
motivation, sleep, arousal, feeding, immune function, maternal behaviors, and lactation …

Fatty acid binding proteins (FABPs) are a family of intracellular lipid chaperone proteins
known to play critical roles in the regulation of fatty acid uptake and transport as well as …

Depression is a major psychiatric disease affecting all ages and is often co-morbid with
neurodegeneration in the elderly. Depression and neurodegeneration are associated with …

The peroxisome proliferator-activated receptor gamma (PPARγ), which belongs to the family
of nuclear receptors, has been mainly studied as an important factor in metabolic disorders …