The physiological control of eating: signals, neurons, and networks
AG Watts, SE Kanoski, G Sanchez-Watts… - Physiological …, 2022 - journals.physiology.org
During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …
Multifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis
Melanin-concentrating hormone (MCH) is a small cyclic peptide expressed in all mammals,
mainly in the hypothalamus. MCH acts as a robust integrator of several physiological …
mainly in the hypothalamus. MCH acts as a robust integrator of several physiological …
[HTML][HTML] Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease
Microglia are critical in brain development and Alzheimer's disease (AD) etiology. Down
syndrome (DS) is the most common genetic developmental disorder and risk factor for AD …
syndrome (DS) is the most common genetic developmental disorder and risk factor for AD …
OLIG2 drives abnormal neurodevelopmental phenotypes in human iPSC-based organoid and chimeric mouse models of down syndrome
Down syndrome (DS) is a common neurodevelopmental disorder, and cognitive defects in
DS patients may arise from imbalances in excitatory and inhibitory neurotransmission …
DS patients may arise from imbalances in excitatory and inhibitory neurotransmission …
The hypocretin (orexin) system: from a neural circuitry perspective
SB Li, L de Lecea - Neuropharmacology, 2020 - Elsevier
Hypocretin/orexin neurons are distributed restrictively in the hypothalamus, a brain region
known to orchestrate diverse functions including sleep, reward processing, food intake …
known to orchestrate diverse functions including sleep, reward processing, food intake …
Control of energy homeostasis by the lateral hypothalamic area
MA Rossi - Trends in neurosciences, 2023 - cell.com
The lateral hypothalamic area (LHA) is a subcortical brain region that exerts control over
motivated behavior, feeding, and energy balance across species. Recent single-cell …
motivated behavior, feeding, and energy balance across species. Recent single-cell …
Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism
Z Huang, L Liu, J Zhang, K Conde, J Phansalkar… - Science …, 2022 - science.org
Glucagon-like peptide-1 (GLP-1) regulates energy homeostasis via activation of the GLP-1
receptors (GLP-1Rs) in the central nervous system. However, the mechanism by which the …
receptors (GLP-1Rs) in the central nervous system. However, the mechanism by which the …
To eat or to sleep: That is a lateral hypothalamic question
E Arrigoni, MJS Chee, PM Fuller - Neuropharmacology, 2019 - Elsevier
The lateral hypothalamus (LH) is a functionally and anatomically complex brain region that
is involved in the regulation of many behavioral and physiological processes including …
is involved in the regulation of many behavioral and physiological processes including …
Hedonic eating and the “delicious circle”: from lipid-derived mediators to brain dopamine and back
R Coccurello, M Maccarrone - Frontiers in neuroscience, 2018 - frontiersin.org
Palatable food can be seductive and hedonic eating can become irresistible beyond hunger
and negative consequences. This is witnessed by the subtle equilibrium between eating to …
and negative consequences. This is witnessed by the subtle equilibrium between eating to …
[HTML][HTML] Transcriptional and functional divergence in lateral hypothalamic glutamate neurons projecting to the lateral habenula and ventral tegmental area
The lateral hypothalamic area (LHA) regulates feeding-and reward-related behavior, but
because of its molecular and anatomical heterogeneity, the functions of defined neuronal …
because of its molecular and anatomical heterogeneity, the functions of defined neuronal …