The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive …

The transient receptor potential vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1, respectively)
channels are members of the TRP superfamily of structurally related, non‐selective cation …

Pain normally subserves a vital role in the survival of the organism, prompting the avoidance
of situations associated with tissue damage. However, the sensation of pain can become …

Mechanical hyperalgesia is a clinically-relevant form of pain sensitization that develops
through largely unknown mechanisms. TRPA1, a Transient Receptor Potential ion channel …

The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed in pain-sensing
neurons and other tissues and has become a major target in the development of novel …

The plant cannabinoids (phytocannabinoids), cannabidiol (CBD), and Δ9-
tetrahydrocannabinol (THC) were previously shown to activate transient receptor potential …

Objective Migraine is three times more common in women. CGRP plays a critical role in
migraine pathology and causes female‐specific behavioral responses upon meningeal …

According to the International Association for the Study of Pain (IASP) pain is characterized
as an “unpleasant sensory and emotional experience associated with actual or potential …

The transient receptor potential A1 (TRPA1) channel is the molecular target for
environmental irritants and pungent chemicals, such as cinnamaldehyde and mustard oil …

The molecular mechanism of action of Δ 9-tetrahydrocannabinol (THC), the psychotropic
constituent of Cannabis, has been a puzzle during the three decades separating its …