Rationale: Inflammation and thrombosis are related via interactions between leukocytes,
platelets, the vasculature, and the coagulation system. However, the mechanisms behind …

Although early events in the pathogenesis of acute lung injury (ALI) have been defined, little
is known about the mechanisms mediating resolution. To search for determinants of …

Horses are unique in their extreme sensitivity to endotoxin-induced cardio-pulmonary shock
and mortality. The mechanisms behind increased sensitivity of the horse to endotoxin …

Acute lung injury (ALI) is a clinical syndrome characterized by acute respiratory failure and is
associated with substantial morbidity and mortality. Rhesus θ-defensin (RTD)-1 is an …

Airway epithelial cells secrete proinflammatory mediators in response to LPS, but cytokine
production by a prominent nonciliated bronchiolar epithelial cell, the Clara cell, specifically …

Bacterial products (such as endotoxins and flagellin) trigger innate immune responses
through TLRs. Flagellin‐induced signalling involves TLR5 and MyD88 and, according to …

Airway inflammation induced by reactive oxygen species-mediated activation of redox-
sensitive transcription factors is the hallmark of asthma, a prevalent chronic respiratory …

Xiebai San (XBS) is a traditional Chinese medicine (TCM) prescription that has been widely
used to treat pediatric pneumonia since the Song dynasty. To reveal its underlying working …

Macrophages are a well recognized player of both innate and adaptive immunity and have
emerged as a key regulator of systemicmetabolism, hematopoiesis, vasculogenesis …

Although inflammation plays a central role in the pathogenesis of acute lung injury, the
molecular mechanisms underlying inflammatory responses in acute lung injury are poorly …