The bone marrow (BM) is the primary site of adult haematopoiesis, where stromal elements
(eg fibroblasts and mesenchymal stem cells [MSCs]) work in concert to support blood cell …

Both the cascade whereby a blood-borne cell enters a tissue and the anchoring of
hematopoietic stem/progenitor cells (HSPCs) within bone marrow critically pivots on cell-cell …

Bone marrow microenvironment (BMM) has been proven to have benefits for both normal
hematopoietic stem cell niche and pathological leukemic stem cell niche. In fact, the …

In the bone marrow (BM) of adult mammals, haematopoietic stem cells (HSCs) are retained
in micro-anatomical structures by adhesion molecules that regulate HSC quiescence …

CD44 is a ubiquitous leukocyte adhesion molecule involved in cell-cell interaction, cell
adhesion, migration, homing and differentiation. CD44 can mediate the interaction between …

The role of the vascular microenvironment is increasingly studied in acute myeloid
leukaemia (AML). Complex interactions between endothelial cells (ECs) and pre-leukaemic …

Integrins, which consist of two non-covalently linked α and β subunits, play a crucial role in
cell–cell adhesion and cell-extracellular matrix (ECM) interactions. Among them, integrin β1 …

Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy that
strongly correlates with poor clinical outcomes. Ferroptosis is an iron-dependent, non …

The protein family of aldehyde dehydrogenases (ALDH) encompasses nineteen members.
The ALDH1 subfamily consists of enzymes with similar activity, having the capacity to …

Acute myeloid leukaemia (AML) continues to have a poor prognosis, warranting new
therapeutic strategies. The bone marrow (BM) microenvironment consists of niches that …