The pathogenesis of gastroesophageal reflux disease (GERD) is complex and involves
changes in reflux exposure, epithelial resistance, and visceral sensitivity. The gastric …

Up to 40% of patients with symptoms suspicious of gastroesophageal reflux disease (GERD)
do not respond completely to proton pump inhibitor (PPI) therapy. The term “refractory …

Approximately a third of patients with suspected gastro-oesophageal reflux disease are
resistant or partial responders to proton pump inhibitors (PPIs). Many of these patients do …

Patients with gastro-oesophageal reflux disease (GORD) who are not responding to proton
pump inhibitors (PPIs) given once daily are very common. Various underlying mechanisms …

Abstract Background/Aims: Although considerable information exists regarding
gastroesophageal reflux disease with erosions, much less is known of non-erosive reflux …

It has been demonstrated that 44% of the US population report gastroesophageal reflux
disease (GERD)-related symptoms at least once a month and 20% once a week. 1, 2 …

Background & Aims: Most patients with gastroesophageal reflux disease (GERD) report that
stress exacerbates their symptoms, yet mechanisms underlying this association remain …

Methods Fifty proton pump inhibitotor refractory patients (11 male, 48 years [range, 38–57
years]) with a diagnosis of functional heart-burn according to Rome III in the first 24 hours of …

Refractory gastroesophageal reflux disease (GERD) is very common and may affect up to
40% of patients who use a proton pump inhibitor (PPI) once daily. Refractory GERD can …

Proton-pump inhibitor (PPI) failure in gastro-oesophageal reflux disease (GORD) patients
has become the main reason for referral of these patients to gastroenterology specialists. It …