[HTML][HTML] Type 2 diabetes and Alzheimer's disease: the emerging role of cellular lipotoxicity

N Marrano, G Biondi, A Borrelli, M Rella, T Zambetta… - Biomolecules, 2023 - mdpi.com
Type 2 diabetes (T2D) and Alzheimer's diseases (AD) represent major health issues that
have reached alarming levels in the last decades. Although growing evidence demonstrates …

[HTML][HTML] Roles of the unsaturated fatty acid docosahexaenoic acid in the central nervous system: Molecular and cellular insights

AB Petermann, M Reyna-Jeldes, L Ortega… - International Journal of …, 2022 - mdpi.com
Fatty acids (FAs) are essential components of the central nervous system (CNS), where they
exert multiple roles in health and disease. Among the FAs, docosahexaenoic acid (DHA) …

[HTML][HTML] Environmental stimulation in Huntington disease patients and animal models

A Novati, HP Nguyen, J Schulze-Hentrich - Neurobiology of Disease, 2022 - Elsevier
While Huntington disease (HD) is caused solely by a polyglutamine expansion in the
huntingtin gene, environmental factors can influence HD onset and progression. Here, we …

[HTML][HTML] Cleistocalyx nervosum var. paniala Berry Promotes Antioxidant Response and Suppresses Glutamate-Induced Cell Death via SIRT1/Nrf2 Survival Pathway …

W Nantacharoen, SJ Baek, W Plaingam… - Molecules, 2022 - mdpi.com
Excessive glutamate neurotransmitters result in oxidative neurotoxicity, similar to
neurodegeneration. An indigenous berry of Thailand, Cleistocalyx nervosum var. paniala …

[HTML][HTML] Targeting dysregulated lipid metabolism for the treatment of Alzheimer's disease and Parkinson's disease: Current advancements and future prospects

B Tong, Y Ba, Z Li, C Yang, K Su, H Qi, D Zhang… - Neurobiology of …, 2024 - Elsevier
Alzheimer's and Parkinson's diseases are two of the most frequent neurological diseases.
The clinical features of AD are memory decline and cognitive dysfunction, while PD mainly …

[HTML][HTML] Bidirectional communication between brain and visceral white adipose tissue: its potential impact on Alzheimer's disease

X Huang, YJ Wang, Y Xiang - EBioMedicine, 2022 - thelancet.com
A variety of axes between brain and abdominal organs have been reported, but the
interaction between brain and visceral white adipose tissue (vWAT) remains unclear. In this …

[HTML][HTML] Acrolein adducts and responding autoantibodies correlate with metabolic disturbance in Alzheimer's disease

MR Sanotra, SH Kao, CK Lee, CH Hsu… - Alzheimer's Research & …, 2023 - Springer
Alzheimer's disease (AD) is caused by many intertwining pathologies involving metabolic
aberrations. Patients with metabolic syndrome (MetS) generally show hyperglycemia and …

[HTML][HTML] Future foods, dietary factors and healthspan

K Li, C Wang, Y Wang, L Fu, N Zhang - Journal of Future Foods, 2023 - Elsevier
Ageing is a universal decline of physiological functions accompanied by an increase in risks
of developing morbidity, diseases, and death. Calorie restriction (CR) without malnutrition …

[HTML][HTML] Decanoic Acid Rescues Differences in AMPA-Mediated Calcium Rises in Hippocampal CA1 Astrocytes and Neurons in the 5xFAD Mouse Model of …

M Abghari, JTCM Vu, N Eckberg, BI Aldana… - Biomolecules, 2023 - mdpi.com
Alzheimer's disease (AD), a devastating neurodegenerative disease characterized by
cognitive dysfunctions, is associated with high levels of amyloid beta 42 (Aβ42), which is …

Fish oil omega-3 Fatty Acids Alleviate Postoperative delirium-like Behavior in aged mice by Attenuating Neuroinflammation and Oxidative Stress

M Zhu, M Li, S Yang, J Li, C Gong, Q Yu, C Chen… - Neurochemical …, 2024 - Springer
Postoperative delirium (POD) is a common and serious neuropsychiatric syndrome among
older patients, and lacks effective therapies. Omega-3 fatty acids, possessing anti …