Validated computer simulations of the airflow and particle dynamics in human nasal cavities
are important for local, segmental and total deposition predictions of both inhaled toxic and …

Background: Aerosol drug delivery during noninvasive ventilation (NIV) is known to be
inefficient due to high depositional losses. To improve drug delivery efficiency, the concept …

Nasal airway obstruction (NAO) is one of the main problems in the upper part of the human
respiratory system. NAO may considerably affect the airflow and the behavior of droplets in …

Rodents are routinely used in inhalation toxicology tests as human surrogates. However, in
vitro dosimetry tests in rodent casts are still scarce due to small rodent airways and in vitro …

Background: Intranasal delivery protocols that can effectively deposit drugs to the olfactory
region are severely lacking. Furthermore, it is still challenging to quantify nasal deposition …

A critical factor affecting the accuracy of Computational Fluid Dynamic (CFD) simulations
and the time required to conduct them is construction of the computational mesh. This study …

This is a two-part paper describing inhaled nanoparticle (NP) transport and deposition in a
model of a human respiratory tract (Part I) as well as NP-mass transfer across barriers into …

Submicrometer and especially fine aerosols that enter the respiratory tract are largely
exhaled. However, the deposition of these aerosols under expiratory conditions is not well …

The orientation of the nostrils is thought to regulate airflow dynamics and associated
functions of the nose. Previous studies have used different nostril orientations ranging from …

Successful delivery of drugs to the Olfactory region (OR) is the key to treating diseases
through the nasal cavity. The purpose of this paper is to investigate the effect of auxiliary …