Liquid film translocation significantly enhances nasal spray delivery to olfactory region: A numerical simulation study

XA Si, M Sami, J Xi - Pharmaceutics, 2021 - mdpi.com
Previous in vivo and ex vivo studies have tested nasal sprays with varying head positions to
enhance the olfactory delivery; however, such studies often suffered from a lack of …

Effects of guiding vanes and orifice jet flow of a metered-dose inhaler on drug dosimetry in human respiratory tract

XA Si, M Talaat, J Xi - Experimental and Computational Multiphase Flow, 2023 - Springer
Accurate modeling and simulation of metered-dose inhaler (MDI) drug delivery require
detailed information about the spray aerosols and carrier airflows, which are sensitive to the …

Efficient nose-to-lung (N2L) aerosol delivery with a dry powder inhaler

PW Longest, L Golshahi, SRB Behara… - Journal of Aerosol …, 2015 - liebertpub.com
Purpose: Delivering aerosols to the lungs through the nasal route has a number of
advantages, but its use has been limited by high depositional loss in the extrathoracic …

Modelling the transport of expelled cough particles using an Eulerian approach and the variational multiscale method

A Bayram, A Korobenko - Atmospheric Environment, 2022 - Elsevier
Modelling the dispersion and deposition of expelled particles in an indoor environment is
presented in this paper. The airflow is described by the incompressible Navier–Stokes …

Deposition fraction of ellipsoidal fibers in a model of human nasal cavity for laminar and turbulent flows

MM Tavakol, E Ghahramani, O Abouali… - Journal of Aerosol …, 2017 - Elsevier
In this study, the deposition fraction of ellipsoidal fibers in a realistic model of a human nasal
cavity was evaluated for laminar and turbulent airflow conditions. The mean flow field was …

Numerical investigation of septal deviation effect on deposition of nano/microparticles in human nasal passage

H Moghadas, O Abouali, A Faramarzi… - Respiratory physiology & …, 2011 - Elsevier
Three dimensional computational models of both sides of human nasal passages were
developed to investigate the effect of septal deviation on the flow patterns and deposition of …

Inertial particle deposition in a 90 laminar flow bend: An Eulerian fluid particle approach

M Pilou, S Tsangaris, P Neofytou… - Aerosol Science and …, 2011 - Taylor & Francis
A numerical model for the simulation of aerosol flows via an Eulerian–Eulerian, one-way
coupled, two-phase flow description is presented. An in-house computational fluid dynamics …

Hygroscopic aerosol deposition in the human upper respiratory tract under various thermo-humidity conditions

J Xi, J Kim, XA Si, Y Zhou - Journal of Environmental Science and …, 2013 - Taylor & Francis
The deposition of hygroscopic aerosols is highly complex in nature, which results from a
cumulative effect of dynamic particle growth and the real-time size-specific deposition …

[PDF][PDF] Exposure to a COVID-19 carrier: transmission trends in respiratory tract and estimation of infectious dose

S Basu - medRxiv, 2020 - scholar.archive.org
How human respiratory physiology and inhaled airflow therein proceed to impact
transmission of SARS-CoV-2, leading to the initial infection, is an open question. An answer …

Data-driven discovery of anomaly-sensitive parameters from uvula wake flows using wavelet analyses and Poincaré maps

X Si, J Wang, H Dong, J Xi - Acoustics, 2023 - mdpi.com
This study presents a data-driven approach to identifying anomaly-sensitive parameters
through a multiscale, multifaceted analysis of simulated respiratory flows. The anomalies …