Transient receptor potential vanilloid 4 (TRPV4) is widely expressed in the central nervous
system and can be activated by multiple stimuli during cerebral ischemia. Recently, we …

Because clinical trials of pharmacological neuroprotective strategies in stroke have been
disappointing, attention has turned to the brain's own endogenous strategies for …

The AKT, GSK3 and JNK family kinases have been implicated in neuronal apoptosis
associated with neuronal development and several neurodegenerative conditions …

Patients with diabetes are at higher risk of stroke and experience increased morbidity and
mortality after stroke. We hypothesized that cortical neurons develop insulin resistance …

Apoptosis has been proven to play a crucial role in early brain injury pathogenesis and to
represent a target for the treatment of subarachnoid hemorrhage (SAH). Previously, we …

Ethnopharmacological relevance Alkaloids isolated from Uncaria rhynchophylla (Miq.) Miq.
ex Havil.(Rubiaceae), alkaloids (URA) have been used to treat diseases related to the …

Binding of activated protein C (APC) to cells triggers multiple beneficial cytoprotective
activities that suppress apoptosis, inflammation, and endothelial barrier breakdown. One …

Glaucoma is a complex neurodegenerative disease characterized by optic nerve damage
and apoptotic retinal ganglion cell (RGC) death, and is the leading cause of irreversible …

Background Docosahexaenoic acid, a major omega-3 essential fatty acid family member,
improves behavioral deficit and reduces infarct volume and edema after experimental focal …

Phosphatase and tensin homolog (PTEN) is a tumor suppressor due to its ability to regulate
cell survival, growth, and proliferation by downregulating the PI3K/AKT signaling pathway. In …