Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen

N Bostanci, GN Belibasakis - FEMS microbiology letters, 2012 - academic.oup.com
Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the
pathogenesis of periodontitis, an inflammatory disease that destroys the tissues supporting …

The periodontal pocket: pathogenesis, histopathology and consequences

DD Bosshardt - Periodontology 2000, 2018 - Wiley Online Library
The conversion of junctional epithelium to pocket epithelium is regarded as a hallmark in the
development of periodontitis. Knowledge of factors contributing to the initiation and …

Molecular strategies underlying Porphyromonas gingivalis virulence

IL Silva, E Cascales - Journal of Molecular Biology, 2021 - Elsevier
The anaerobic Gram-negative bacterium Porphyromonas gingivalis is considered the
keystone of periodontitis diseases, a set of inflammatory conditions that affects the tissues …

[HTML][HTML] Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation …

Y Guo, KA Nguyen, J Potempa - Periodontology 2000, 2010 - ncbi.nlm.nih.gov
Arguably periodontitis is the most prevalent bacteria-driven chronic inflammatory disease of
the humankind. The incidence of periodontal disease has been reported to range from 30 …

The junctional epithelium: from health to disease

DD Bosshardt, NP Lang - Journal of dental research, 2005 - journals.sagepub.com
The junctional epithelium is located at a strategically important interface between the
gingival sulcus, populated with bacteria, and the periodontal soft and mineralized …

[HTML][HTML] Local and Systemic Effects of Porphyromonas gingivalis Infection

WA Chen, Y Dou, HM Fletcher, DS Boskovic - Microorganisms, 2023 - mdpi.com
Porphyromonas gingivalis, a gram-negative anaerobe, is a leading etiological agent in
periodontitis. This infectious pathogen can induce a dysbiotic, proinflammatory state within …

[HTML][HTML] Bacterial invasion of epithelial cells and spreading in periodontal tissue

GD Tribble, RJ Lamont - Periodontology 2000, 2010 - ncbi.nlm.nih.gov
The composition of the subgingival bacterial microbiota is a critical determinant in the health
status of periodontal tissues. Gram-negative anaerobes such as Porphyromonas gingivalis …

Involvement of integrins in fimbriae‐mediated binding and invasion by Porphyromonas gingivalis

Ö Yilmaz, K Watanabe, RJ Lamont - Cellular microbiology, 2002 - Wiley Online Library
Interaction between the major fimbriae of Porphyromonas gingivalis and gingival epithelial
cells is important for bacterial adhesion and invasion. In this study, we identified integrins as …

Iron and heme utilization in Porphyromonas gingivalis

T Olczak, W Simpson, X Liu… - FEMS microbiology …, 2005 - academic.oup.com
Porphyromonas gingivalis is a Gram-negative anaerobic bacterium associated with the
initiation and progression of adult periodontal disease. Iron is utilized by this pathogen in the …

Porphyromonas gingivalis-Epithelial Cell Interactions in Periodontitis

E Andrian, D Grenier… - Journal of dental …, 2006 - journals.sagepub.com
Emerging data on the consequences of the interactions between invasive oral bacteria and
host cells have provided new insights into the pathogenesis of periodontal disease. Indeed …