The increasing burden of heart failure (HF) and emerging knowledge regarding chloride as
a prognostic marker in HF have increased the interest in the pathophysiology and …

Acute kidney injury (AKI) is a major public health problem that complicates 10–40% of
hospital admissions. Importantly, AKI is independently associated with increased risk of …

Background Low serum chloride is common in patients with chronic heart failure (CHF) and
is associated with worse outcomes. We investigated the clinical and prognostic associations …

Aims Mechanical ultrafiltration (UF) involves the removal of an iso‐osmotic filtrate from the
blood. Its benefit in acute decompensated heart failure, however, remains inconclusive. We …

Clinical guidelines include diuretics for the treatment of heart failure (HF), not to decrease
mortality but to decrease symptoms and hospitalizations. More attention has been paid to …

Despite significant advances in management, heart failure continues to impose a significant
epidemiologic burden with high prevalence and mortality rates. For decades, sodium has …

Aims Prior cohorts demonstrating the importance of serum chloride levels in heart failure
either excluded or had partial representation of patients with heart failure with preserved …

Background: Although hyponatremia predicts morbidity and mortality in acute
decompensated heart failure (ADHF), hypochloremia is also independently associated with …

Hypochloraemia is a common electrolyte abnormality in patients with heart failure (HF). It
has a strong association with adverse outcome regardless of HF phenotype and …

Background Approximately half of people with heart failure have chronic kidney disease
(CKD). Pharmacological interventions for heart failure in people with CKD have the potential …