[HTML][HTML] Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration
A Więckowska-Gacek, A Mietelska-Porowska… - Ageing research …, 2021 - Elsevier
An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …
Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress
S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …
The relationship between obesity and cognitive health and decline
The relationship between obesity and cognitive impairment is important given the globally
ageing population in whom cognitive decline and neurodegenerative disorders will carry …
ageing population in whom cognitive decline and neurodegenerative disorders will carry …
[HTML][HTML] Type 2 diabetes mellitus and Alzheimer's disease: role of insulin signalling and therapeutic implications
A Tumminia, F Vinciguerra, M Parisi… - International journal of …, 2018 - mdpi.com
In the last two decades, numerous in vitro studies demonstrated that insulin receptors and
theirs downstream pathways are widely distributed throughout the brain. This evidence has …
theirs downstream pathways are widely distributed throughout the brain. This evidence has …
[HTML][HTML] Insulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's disease
E Blázquez, E Velázquez… - Frontiers in …, 2014 - frontiersin.org
Although the brain has been considered an insulin-insensitive organ, recent reports on the
location of insulin and its receptors in the brain have introduced new ways of considering …
location of insulin and its receptors in the brain have introduced new ways of considering …
Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer's disease
Type 2 diabetes (T2DM), Alzheimer's disease (AD), and insulin resistance are age‐related
conditions and increased prevalence is of public concern. Recent research has provided …
conditions and increased prevalence is of public concern. Recent research has provided …
[HTML][HTML] Glucagon-like peptide-1: a focus on neurodegenerative diseases
M Grieco, A Giorgi, MC Gentile, M d'Erme… - Frontiers in …, 2019 - frontiersin.org
Diabetes mellitus is one of the major risk factors for cognitive dysfunction. The pathogenesis
of brain impairment caused by chronic hyperglycemia is complex and includes …
of brain impairment caused by chronic hyperglycemia is complex and includes …
[HTML][HTML] Role of the blood-brain barrier in central nervous system insulin resistance
The blood-brain barrier (BBB) mediates the communication between the periphery and the
central nervous system (CNS). Recently, CNS insulin resistance has been elucidated to play …
central nervous system (CNS). Recently, CNS insulin resistance has been elucidated to play …
Treatment strategies against diabetes: Success so far and challenges ahead
R Khursheed, SK Singh, S Wadhwa, B Kapoor… - European journal of …, 2019 - Elsevier
The growing disease burden of diabetes mellitus is an important public health concern,
affecting over 400 million people globally. This epidemic, if not controlled in time, leads to …
affecting over 400 million people globally. This epidemic, if not controlled in time, leads to …
Insulin resistance and neurodegeneration: progress towards the development of new therapeutics for Alzheimer's disease
SM De la Monte - Drugs, 2017 - Springer
Alzheimer's disease (AD) should be regarded as a degenerative metabolic disease caused
by brain insulin resistance and deficiency, and overlapping with the molecular, biochemical …
by brain insulin resistance and deficiency, and overlapping with the molecular, biochemical …