Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …

Active research at the frontiers of immunology and neuroscience has identified multiple
points of interaction and communication between the immune system and the nervous …

The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

The nervous system, the immune system, and microbial pathogens interact closely at barrier
tissues. Here, we find that a bacterial pathogen, Streptococcus pyogenes, hijacks pain and …

Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …

Background Although the cytokine IL-31 has been implicated in inflammatory and lymphoma-
associated itch, the cellular basis for its pruritic action is yet unclear. Objective We sought to …

Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …

The epidermis closely interacts with nerve endings, and both epidermis and nerves produce
substances for mutual sustenance. Neuropeptides, like substance P (SP) and calcitonin …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …