Toxic effects of glyphosate on the nervous system: a systematic review

C Costas-Ferreira, R Durán, LRF Faro - International journal of molecular …, 2022 - mdpi.com
Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is the most widely
used herbicide in the world. It can persist in the environment for days or months, and its …

Role of nuclear factor kappa B (NF-κB) signalling in neurodegenerative diseases: an mechanistic approach

S Singh, TG Singh - Current Neuropharmacology, 2020 - ingentaconnect.com
A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …

[HTML][HTML] Exposure to polystyrene microplastics impairs hippocampus-dependent learning and memory in mice

CW Lee, LF Hsu, IL Wu, YL Wang, WC Chen… - Journal of hazardous …, 2022 - Elsevier
Microplastics (MPs) pollution has become a serious environmental issue worldwide, but its
potential effects on health remain unknown. The administration of polystyrene MPs (PS …

Anti-inflammatory effect of sulforaphane on LPS-activated microglia potentially through JNK/AP-1/NF-κB inhibition and Nrf2/HO-1 activation

L Subedi, JH Lee, S Yumnam, E Ji, SY Kim - Cells, 2019 - mdpi.com
Sulforaphane (SFN), a potent nuclear factor erythroid 2-related factor 2 (Nrf2) activator, is
present in the species of the Brassicaceae, especially in broccoli sprouts. In this study, the …

MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas

R Sigaud, TK Albert, C Hess, T Hielscher… - Nature …, 2023 - nature.com
Pediatric low-grade gliomas (pLGG) show heterogeneous responses to MAPK inhibitors
(MAPKi) in clinical trials. Thus, more complex stratification biomarkers are needed to identify …

The janus face of VEGF in stroke

SJ Geiseler, C Morland - International journal of molecular sciences, 2018 - mdpi.com
The family of vascular endothelial growth factors (VEGFs) are known for their regulation of
vascularization. In the brain, VEGFs are important regulators of angiogenesis …

Regulation of senescence traits by MAPKs

C Anerillas, K Abdelmohsen, M Gorospe - Geroscience, 2020 - Springer
A phenotype of indefinite growth arrest acquired in response to sublethal damage, cellular
senescence affects normal aging and age-related disease. Mitogen-activated protein …

Biological mechanisms of aging predict age‐related disease co‐occurrence in patients

HC Fraser, V Kuan, R Johnen, M Zwierzyna… - Aging …, 2022 - Wiley Online Library
Genetic, environmental, and pharmacological interventions into the aging process can
confer resistance to multiple age‐related diseases in laboratory animals, including rhesus …

The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions

M Takalo, R Wittrahm, B Wefers, S Parhizkar… - Molecular …, 2020 - Springer
Background Microglia-specific genetic variants are enriched in several neurodegenerative
diseases, including Alzheimer's disease (AD), implicating a central role for alterations of the …

Intranasal oxytocin attenuates cognitive impairment, β-amyloid burden and tau deposition in female rats with Alzheimer's disease: interplay of ERK1/2/GSK3β/caspase …

SO El-Ganainy, OA Soliman, AA Ghazy, M Allam… - Neurochemical …, 2022 - Springer
Oxytocin is a neuropeptide hormone that plays an important role in social bonding and
behavior. Recent studies indicate that oxytocin could be involved in the regulation of …