Viral dynamics and real-time RT-PCR Ct values correlation with disease severity in COVID-19

AA Rabaan, R Tirupathi, AA Sule, J Aldali, AA Mutair… - Diagnostics, 2021 - mdpi.com
Real-time RT-PCR is considered the gold standard confirmatory test for coronavirus disease
2019 (COVID-19). However, many scientists disagree, and it is essential to understand that …

Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention

E Shirbhate, J Pandey, VK Patel, M Kamal… - Pharmacological …, 2021 - Springer
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with
hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular …

Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization

Y Wu, X Cheng, G Jiang, H Tang, S Ming… - npj Biofilms and …, 2021 - nature.com
The human oral and gut commensal microbes play vital roles in the development and
maintenance of immune homeostasis, while its association with susceptibility and severity of …

Polymorphisms of ACE (I/D) and ACE2 receptor gene (Rs2106809, Rs2285666) are not related to the clinical course of COVID‐19: A case study

S Karakaş Çelik, G Çakmak Genç… - Journal of Medical …, 2021 - Wiley Online Library
Coronavirus disease 2019 (COVID‐19) is an infectious disease, and the reason behind the
currently ongoing pandemic, caused by severe acute respiratory syndrome coronavirus 2 …

Diagnostic SARS-CoV-2 cycle threshold value predicts disease severity, survival, and six-month sequelae in COVID-19 symptomatic patients

M Trunfio, F Venuti, F Alladio, BM Longo, E Burdino… - Viruses, 2021 - mdpi.com
To date, there is no severe acute respiratory syndrome coronavirus 2-(SARS-CoV-2)-
specific prognostic biomarker available. We assessed whether SARS-CoV-2 cycle threshold …

Endothelial cells in emerging viral infections

JH Fosse, G Haraldsen, K Falk… - Frontiers in cardiovascular …, 2021 - frontiersin.org
There are several reasons to consider the role of endothelial cells in COVID-19 and other
emerging viral infections. First, severe cases of COVID-19 show a common breakdown of …

Long COVID, neuropsychiatric disorders, psychotropics, present and future

SW Tang, BE Leonard, DM Helmeste - Acta neuropsychiatrica, 2022 - cambridge.org
Long COVID refers to the lingering symptoms which persist or appear after the acute illness.
The dominant long COVID symptoms in the two years since the pandemic began (2020 …

Development of targeted nanoparticles loaded with antiviral drugs for SARS-CoV-2 inhibition

V Sanna, S Satta, T Hsiai, M Sechi - European Journal of Medicinal …, 2022 - Elsevier
Recently, a novel coronavirus, known as severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has raised global concerns, being the etiological agent of the current …

Meta-analysis of 16S rRNA microbial data identified alterations of the gut microbiota in COVID-19 patients during the acute and recovery phases

X Cheng, Y Zhang, Y Li, Q Wu, J Wu, SK Park, C Guo… - BMC microbiology, 2022 - Springer
Background Dozens of studies have demonstrated gut dysbiosis in COVID-19 patients
during the acute and recovery phases. However, a consensus on the specific COVID-19 …

The potential of probiotics as ingestible adjuvants and immune modulators for antiviral immunity and management of SARS-CoV-2 infection and COVID-19

S Tomkinson, C Triscott, E Schenk, A Foey - Pathogens, 2023 - mdpi.com
Probiotic bacteria are able to modulate general antiviral responsiveness, including barrier
functionality and innate and adaptive immune responses. The COVID-19 pandemic …