Tissues stiffen during aging and during the pathological progression of cancer, fibrosis, and
cardiovascular disease. Extracellular matrix stiffness is emerging as a prominent mechanical …

Simple Summary The gut microbiome affects the development of systemic immune response
and it can also impact response to systemic treatments such as immunotherapy and …

Bacterial toxins are virulence factors that manipulate host cell functions and take over the
control of vital processes of living organisms to favor microbial infection. Some toxins directly …

Bacterial AB-type toxins are proteins released by the producing bacteria and are the
causative agents for several severe diseases including cholera, whooping cough, diphtheria …

Botulinum toxin (BoNT) is a potent neurotoxin that poses a significant threat as a biowarfare
weapon and a potential bioterrorist tool. Currently, there is a lack of effective …

A facile chemical approach integrating supramolecular chemistry, site‐selective protein
chemistry, and molecular biology is described to engineer synthetic multidomain protein …

The protein toxin C3bot from Clostridium botulinum is a mono-ADP-ribosyltransferase that
selectively intoxicates monocyte-derived cells such as macrophages, osteoclasts, and …

There is a growing body of evidence supporting the significant role of bacterial biofilms in
the pathogenesis of various human diseases, including cancer. Biofilms are polymicrobial …

C3larvinA is a putative virulence factor produced by Paenibacillus larvae enterobacterial-
repetitive-intergenic-consensus (ERIC) III/IV (strain 11-8051). Biochemical, functional and …

Bacterial protein toxins are secreted by certain bacteria and are responsible for mild to
severe diseases in humans and animals. They are among the most potent molecules …