Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

The ability of a cell to undergo mitochondrial apoptosis is governed by pro-and anti-
apoptotic members of the BCL-2 protein family. The equilibrium of pro-versus anti-apoptotic …

Abstract MCL1 (myeloid cell leukemia-1) is a widely recognized pro-survival member of the
Bcl-2 (B-cell lymphoma protein 2) family and a promising target for cancer therapy. While the …

The mitochondrial caspase cascade was originally thought to be required for apoptotic
death driven by Bak/Bax-mediated intrinsic apoptosis. It has also been ascribed several 'non …

BCL-2 molecules are regulators of programmed cell death and defects in this pathway
contribute to human diseases. One family member, MCL-1, is unique because its expression …

Despite their profoundly different cellular composition, size, and function, megakaryocytes
and platelets both depend on restraint of the intrinsic (or “mitochondrial”) apoptosis pathway …

Platelets are anucleate cytoplasmic discs derived from megakaryocytes that circulate in the
blood and have major roles in hemostasis, thrombosis, inflammation, and vascular biology …

Regulation of both the extrinsic and the mitochondria-dependent intrinsic apoptotic
pathways plays a key role in the development of the hematopoietic system, for sustaining …

The role of apoptotic pathways in the development and function of the megakaryocyte
lineage has generated renewed interest in recent years. This has been driven by the advent …

The lifespan of platelets in circulation is brief, close to 10 days in humans and 5 days in
mice. Bone marrow residing megakaryocytes produce around 100 billion platelets per day …