Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

Vascular endothelial growth factor receptors (VEGFRs) are a family of receptor protein
tyrosine kinases that play an important role in the regulation of tumor-induced angiogenesis …

Triple negative breast cancer (TNBC) has a negative expression of estrogen receptors (ER),
progesterone receptors (PR), and human epidermal growth factor receptors (HER2). The …

Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the
worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell …

Selective degradation of the cyclin-dependent kinases 12 and 13 (CDK12/13) presents a
novel therapeutic opportunity for triple-negative breast cancer (TNBC), but there is still a lack …

Sirtuin-3 (SIRT3) is an NAD+-dependent protein deacetylase localized primarily in the
mitochondria with many links to different types of human cancers. Autophagy, which is a …

Multitarget HDAC inhibitors capable of simultaneously blocking the BRD4-LIFR-JAK1-
STAT3 signaling pathway hold great potential for the treatment of TNBC and other solid …

Breast cancer is still one of the most common malignancies worldwide and remains a major
clinical challenge. We previously reported that the anthelmintic drug flubendazole induced …

Triple-negative breast cancer (TNBC) is highly aggressive with very limited treatment
options due to the lack of efficient targeted therapies and thus still remains clinically …

The transcription factor FOXM1 that regulates multiple proliferation-related genes through
selective protein-DNA and protein–protein interactions is now considered an attractive …