miRNAs as potential diagnostic biomarkers and pharmacogenomic indicators in psychiatric disorders

EE Tsermpini, CI Kalogirou… - The …, 2022 - nature.com
The heterogeneity of psychiatric disorders and the lack of reliable biomarkers for prediction
and treatments follow-up pose difficulties towards recognition and understanding of the …

Peripheral biomarkers of treatment-resistant schizophrenia: Genetic, inflammation and stress perspectives

S Jiao, T Cao, H Cai - Frontiers in Pharmacology, 2022 - frontiersin.org
Treatment-resistant schizophrenia (TRS) often results in severe disability and functional
impairment. Currently, the diagnosis of TRS is largely exclusionary and emphasizes the …

Loperamide, a peripheral Mu-Opioid receptor agonist, attenuates chemotherapy-induced neuropathic pain in rats

A Gadepalli, O Ummadisetty, D Chouhan… - International …, 2023 - Elsevier
Opioids are employed in the management of chemotherapy-induced neuropathic pain
(CINP) when other pain management approaches have failed and proven ineffective …

Remote ischemic conditioning alleviates chronic cerebral hypoperfusion-induced cognitive decline and synaptic dysfunction via the miR-218a-5p/SHANK2 pathway

N Li, C Ren, S Li, W Yu, K Jin, X Ji - Progress in Neurobiology, 2023 - Elsevier
Vascular cognitive impairment (VCI) due to chronic cerebral hypoperfusion (CCH), is the
second leading cause of dementia. Although synaptic impairment plays a critical role in VCI …

Treatment-resistant schizophrenia, clozapine resistance, genetic associations, and implications for precision psychiatry: a scoping review

J Ying, QH Chew, RS McIntyre, K Sim - Genes, 2023 - mdpi.com
Treatment-resistant schizophrenia (TRS) is often associated with severe burden of disease,
poor quality of life and functional impairment. Clozapine is the gold standard for the …

miR-218-2 regulates cognitive functions in the hippocampus through complement component 3–dependent modulation of synaptic vesicle release

SY Lu, CL Fu, L Liang, B Yang… - Proceedings of the …, 2021 - National Acad Sciences
microRNA-218 (miR-218) has been linked to several cognition related neurodegenerative
and neuropsychiatric disorders. However, whether miR-218 plays a direct role in cognitive …

[HTML][HTML] Application of miRNA-seq in neuropsychiatry: A methodological perspective

D Pérez-Rodríguez, H López-Fernández… - Computers in Biology …, 2021 - Elsevier
MiRNAs are emerging as key molecules to study neuropsychiatric diseases. However,
despite the large number of methodologies and software for miRNA-seq analyses, there is …

[HTML][HTML] Extracellular microRNAs associated with psychiatric symptoms in the Normative Aging Study

X Qiu, MD Yazdi, C Wang, A Kosheleva, H Wu… - Journal of Psychiatric …, 2024 - Elsevier
Earlier studies have revealed microRNAs (miRNAs) as potential biomarkers for neurological
conditions, however, such evidence on psychiatric outcomes is limited. We utilized the …

[HTML][HTML] The Role of microRNA in Schizophrenia: A Scoping Review

K Li, L Zhu, H Lv, Y Bai, C Guo, K He - International Journal of Molecular …, 2024 - mdpi.com
Schizophrenia is a serious mental disease that is regulated by multiple genes and
influenced by multiple factors. Due to the complexity of its etiology, the pathogenesis is still …

Pharmacogenetic intervention improves treatment outcomes in Chinese adult men with schizophrenia

Y Qin, Y Liu, J Zhao, Y Yang, H Xiang, T Gao… - Journal of Psychiatric …, 2024 - Elsevier
To investigate the clinical application value of pharmacogenetic testing in individualized
drug therapy for adult male patients with schizophrenia. A total of 186 adult patients with …