Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …

Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …

The preclinical phase of autoimmune disorders is characterized by an initial asymptomatic
phase of varying length followed by nonspecific signs and symptoms. A variety of …

For much of the last century, our knowledge regarding the pancreas in type 1 and type 2
diabetes was largely derived from autopsy studies of individuals with these disorders or …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Type 1 diabetes (T1D) is an autoimmune disease characterized by the T-cell-mediated
destruction of insulin-producing β-cells in pancreatic islets. It generally occurs in genetically …

We review the current knowledge of pancreas pathology in type 1 diabetes. During the last
two decades, dedicated efforts toward the recovery of pancreas from deceased patients with …

Understanding the root causes of autoimmune diseases is hampered by the inability to
access relevant human tissues and identify the time of disease onset. To examine the …

Autoimmune β-cell destruction leads to type 1 diabetes, but the pathophysiological
mechanisms remain unclear. To help address this void, we created an open-access online …

Aims/hypothesis Individuals with longstanding and recent-onset type 1 diabetes have a
smaller pancreas. Since beta cells represent a very small portion of the pancreas, the loss of …