Biomimetic strategies for enhancing synthesis and delivery of antibacterial nanosystems

UH Ibrahim, N Devnarain, T Govender - International Journal of …, 2021 - Elsevier
The identification of bacterial infections as a significant human-life threatening challenge is
driving several research efforts toward generating new strategies to treat bacterial infections …

Colonization dynamics of extended-spectrum beta-lactamase-producing Enterobacterales in the gut of Malawian adults

JM Lewis, M Mphasa, R Banda, MA Beale… - Nature …, 2022 - nature.com
Drug-resistant bacteria of the order Enterobacterales which produce extended-spectrum
beta-lactamase enzymes (ESBL-Enterobacterales, ESBL-E) are global priority pathogens …

Effect of resistance to third-generation cephalosporins on morbidity and mortality from bloodstream infections in Blantyre, Malawi: a prospective cohort study

R Lester, P Musicha, K Kawaza, J Langton… - The Lancet …, 2022 - thelancet.com
Background The burden of antimicrobial resistance is a major threat to global health;
however, prospective clinical outcome data from Africa are scarce. In Malawi, third …

Antimicrobial resistance pattern of Klebsiella isolated from various clinical samples in Ethiopia: a systematic review and meta-analysis

L Gebremeskel, T Teklu, GG Kasahun… - BMC Infectious …, 2023 - Springer
Abstract Background The burden of Klebsiella drug resistance to antimicrobials is a major
public health concern worldwide; particularly the problem is severe in developing countries …

Phenotypic and genotypic antibiotic susceptibility profiles of Gram-negative bacteria isolated from bloodstream infections at a referral hospital, Lusaka, Zambia

K Yamba, C Lukwesa-Musyani… - PLOS Global Public …, 2023 - journals.plos.org
Bloodstream infections (BSI) caused by antimicrobial-resistant (AMR) Gram-negative
bacteria (GNB) are a significant cause of morbidity and mortality. Third-generation …

Global Antimicrobial Resistance and Use Surveillance System on the African continent: Early implementation 2017-2019

B Tornimbene, S Eremin, R Abednego… - African Journal of …, 2022 - scielo.org.za
TORNIMBENE, Barbara et al. Global Antimicrobial Resistance and Use Surveillance System
on the African continent: Early implementation 2017-2019. Afr. J. Lab. Med.[online]. 2022 …

Sustained reduction in third-generation cephalosporin usage in adult inpatients following introduction of an antimicrobial stewardship program in a large, urban …

R Lester, K Haigh, A Wood… - Clinical Infectious …, 2020 - academic.oup.com
Background Third-generation cephalosporins (3GC) remain the first-choice empiric
antibiotic for severe infection in many sub-Saharan African hospitals. In Malawi, the limited …

[HTML][HTML] Healthcare-associated infections and antimicrobial use in surgical wards of a large urban central hospital in Blantyre, Malawi: a point prevalence survey

GK Bunduki, N Feasey, MYR Henrion, P Noah… - Infection prevention in …, 2021 - Elsevier
Background There are limited data on healthcare-associated infections (HAI) from African
countries like Malawi. Aim We undertook a point prevalence survey of HAI and antimicrobial …

Mortality associated with third-generation cephalosporin resistance in Enterobacterales bloodstream infections at eight sub-Saharan African hospitals (MBIRA): a …

AM Aiken, AM Rehman, MEA de Kraker… - The Lancet Infectious …, 2023 - thelancet.com
Background Bacteria of the order Enterobacterales are common pathogens causing
bloodstream infections in sub-Saharan Africa and are frequently resistant to third-generation …

Risk Factors, Temporal Dependence, and Seasonality of Human Extended-Spectrum β-Lactamases-Producing Escherichia coli and Klebsiella pneumoniae …

M Sammarro, B Rowlingson, D Cocker… - Clinical Infectious …, 2023 - academic.oup.com
Abstract Background Sub-Saharan Africa has the highest estimated death rate attributable to
antimicrobial resistance, especially from extended-spectrum β-lactamase-producing …