Gene regulatory networks and tissue morphogenetic events drive the emergence of shape
and function: the pillars of embryo development. Although model systems offer a window …

Stem cells in their natural microenvironment are exposed to biochemical and biophysical
cues emerging from the extracellular matrix (ECM) and neighboring cells. In particular …

Background: Extracellular matrix (ECM)-derived mechanical stimuli regulate many cellular
processes and phenotypes through mechanotransduction signaling pathways. Substrate …

Background The accumulating evidence confirms that long non-coding RNAs (lncRNAs)
play a critical regulatory role in the progression of renal cell carcinoma (RCC). But, the …

In mammals, mechanics at multiple stages—nucleus to cell to ECM—underlie multiple
physiological and pathological functions from its development to reproduction to death …

There is increasing evidence that long noncoding RNAs (lncRNAs) are among the main
regulatory factors of stem cell maintenance and differentiation. They act through various …

The matrix stiffness of the extracellular matrix (ECM), which is the slow elastic force on cells,
has gradually become investigated. And a higher stiffness could induce changes in cell …

Single-cell RNA sequencing allows us to model cellular state dynamics and fate decisions
using expression similarity or RNA velocity to reconstruct state-change trajectories; however …

Human embryonic stem cells (hESCs) possess the potential of long-term self-renewal and
three primary germ layers differentiation, and thus hESCs are expected to have broad …

Tissue-resident stem cells are surrounded by a microenvironment known as 'stem cell
niche'which is specific for each stem cell type. This niche comprises of cell-intrinsic and …