The heart and vascular system are susceptible to the harmful effects of alcohol. Alcohol is an
active toxin that undergoes widespread diffusion throughout the body, causing multiple …

An extensive body of data shows concordant J-shaped associations between alcohol intake
and a variety of adverse health outcomes, including coronary heart disease, diabetes …

Objective To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as
an instrument to investigate the causal role of alcohol in cardiovascular disease. Design …

Selection biases may lead to systematic overestimate of protective effects from
'moderate'alcohol consumption. Overall, most sources of selection bias favor low‐volume …

Ethanol affects cognition in a number of ways. Indirect effects include intoxication,
withdrawal, brain trauma, central nervous system infection, hypoglycemia, hepatic failure …

Numerous studies have used a J-shaped or U-shaped curve to describe the relationship
between alcohol use and total mortality. The nadir of the curves based on recent meta …

We review evidence for and against the 'red wine hypothesis', whereby red wine is more
likely to confer cardiovascular benefits than white. As background, there is a strong …

In contrast to many years of important research and clinical attention to the pathological
effects of alcohol (ethanol) abuse, the past several decades have seen the publication of a …

While ethanol intake at high levels (3–4 or more drinks), either in acute (occasional binge
drinking) or chronic (daily) settings, increases the risk for myocardial infarction and stroke …

Mendelian randomisation studies from Asia suggest detrimental influences of alcohol on
cardiovascular risk factors, but such associations are observed mainly in men. The absence …