Stem cell therapy aims to replace damaged or aged cells with healthy functioning cells in
congenital defects, tissue injuries, autoimmune disorders, and neurogenic degenerative …

Cells of unicellular and multicellular eukaryotes can respond to certain environmental cues
by arresting the cell cycle and entering a reversible state of quiescence. Quiescent cells do …

Abstract Background Mesenchymal stem cells (MSCs) possess intrinsic regeneration
capacity as part of the repair process in response to injury, such as fracture or other tissue …

Over 700 drugs have failed in stroke clinical trials, an unprecedented rate thought to be
attributed in part to limited and isolated testing often solely in “young” rodent models and …

BACKGROUND. The tumor immune response is increasingly associated with better clinical
outcomes in breast and other cancers. However, the evaluation of tumor-infiltrating …

The peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of
adipogenesis and is medically important for its connections to obesity and the treatment of …

The pineal gland-derived indoleamine hormone, melatonin, regulates multiple cellular
processes, ranging from chronobiology, proliferation, apoptosis, and oxidative damage to …

Multipotent mesenchymal stromal cells (MSCs) are an attractive cell source for cell therapy
in cartilage. Although their therapeutic potential is clear, the requirements and conditions for …

Stem cells are characterized by their capability to self‐renew and terminally differentiate into
multiple cell types. Somatic or adult stem cells have a finite self‐renewal capacity and are …

Owing to their potential for differentiation into multiple cell types, multipotent stem cells
extracted from many adult tissues are an attractive stem cell resource for the replacement of …