The rising interest in Kv7 modulators originates from their ability to evoke fundamental
electrophysiological perturbations in a tissue-specific manner. A large number of therapeutic …

The KCNQ1 ion channel plays critical physiological roles in electrical excitability and K+
recycling in organs including the heart, brain, and gut. Loss of function is relatively common …

Pre-existing Ca2+ handling abnormalities constitute the arrhythmogenic substrate in
patients developing postoperative atrial fibrillation (POAF), a common complication after …

In cardiac muscle, the process of excitation-contraction coupling (ECC) describes the chain
of events that links action potential induced myocyte membrane depolarization, surface …

Cardiac alternans, defined as beat-to-beat alternations in action potential duration, cytosolic
Ca transient (CaT) amplitude, and cardiac contraction is associated with atrial fibrillation …

At the cellular level, cardiac alternans is observed as beat‐to‐beat alternations in
contraction strength, action potential (AP) morphology and Ca2+ transient (CaT) amplitude …

KCNQ1 is a pore-forming K+ channel subunit critically important to cardiac repolarization at
high heart rates.(2R)-N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl) sulfonyl]-2 …

Carvedilol is a nonspecific β-blocker clinically used for the treatment of cardiovascular
diseases but has also been shown to have profound effects on excitation-contraction …

Atrial fibrillation (AF) is the most persistent arrhythmia today, with its prevalence increasing
exponentially with the rising age of the population. Particularly at elevated heart rates, a …

Cardiac alternans is defined as beat‐to‐beat alternations in contraction strength, action
potential duration (APD), and Ca transient (CaT) amplitude. Cardiac excitation–contraction …