Because of the high demand of organs, the usage of marginal grafts has increased. These
marginal organs have a higher risk of developing ischemia-reperfusion injury, which can …

Background: Machine perfusion (MP) and static cold storage (CS) are two prevalent
methods for liver allograft preservation. However, the preferred method remains …

Background. Better preservation strategies for the storage of donation after circulatory death
grafts are essential to improve graft function and to increase the kidney donor pool. We …

Lesion scores on procurement donor biopsies are commonly used to guide organ utilization
for deceased-donor kidneys. However, frozen sections present challenges for histological …

Background For 50 years, static cold storage (SCS) has been the gold standard for solid
organ preservation in transplantation. Although logistically convenient, this preservation …

Currently trials of immunosuppression in transplantation are in decline because their
objectives remain focused on improving acute rejection rates and graft survival in the first 12 …

Ex-vivo machine perfusion represents a superior organ preservation method over static cold
storage. There is still an urgent need for the optimization of the perfusion fluid and machine …

Hypothermic oxygenated machine perfusion (HOPE) was recently tested in preclinical trials
in kidney transplantation (KT). Here we investigate the effects of HOPE on extended-criteria …

A great deal of research is still needed to optimize and logistically place hypothermic and
normothermic perfusion technologies. In the future, we may progress toward organ-tailored …

Extracellular vesicles (EVs) play an important role in cell-to-cell communication by delivering
coding and non-coding RNA species and proteins to target cells. Recently, the therapeutic …