Hypoxic pulmonary vasoconstriction
JT Sylvester, LA Shimoda, PI Aaronson… - Physiological …, 2012 - journals.physiology.org
It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …
Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms
KR Stenmark, KA Fagan, MG Frid - Circulation research, 2006 - Am Heart Assoc
Chronic hypoxic exposure induces changes in the structure of pulmonary arteries, as well as
in the biochemical and functional phenotypes of each of the vascular cell types, from the …
in the biochemical and functional phenotypes of each of the vascular cell types, from the …
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
YY Aimee, LA Shimoda, NV Iyer… - The Journal of …, 1999 - Am Soc Clin Investig
Chronic hypoxia induces polycythemia, pulmonary hypertension, right ventricular
hypertrophy, and weight loss. Hypoxia-inducible factor 1 (HIF-1) activates transcription of …
hypertrophy, and weight loss. Hypoxia-inducible factor 1 (HIF-1) activates transcription of …
Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics
Cyclic guanosine 3', 5'-monophosphate (cGMP) mediates a wide spectrum of physiologic
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …
A novel murine model of severe pulmonary arterial hypertension
L Ciuclan, O Bonneau, M Hussey… - American journal of …, 2011 - atsjournals.org
Rationale: The complex pathologies associated with severe pulmonary arterial hypertension
(PAH) in humans have been a challenge to reproduce in mice due to the subtle phenotype …
(PAH) in humans have been a challenge to reproduce in mice due to the subtle phenotype …
Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension
Primary pulmonary hypertension is a progressive and often fatal disorder in humans that
results from an increase in pulmonary blood pressure associated with abnormal vascular …
results from an increase in pulmonary blood pressure associated with abnormal vascular …
Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase
Background—Hypoxia-induced pulmonary hypertension is a major cause of morbidity and
mortality. Hypoxia induces pulmonary vasoconstriction, in part, by decreasing endothelial …
mortality. Hypoxia induces pulmonary vasoconstriction, in part, by decreasing endothelial …
Sildenafil inhibits hypoxia-induced pulmonary hypertension
Background This study investigated the effect of the phosphodiesterase 5 inhibitor sildenafil
on the pulmonary vascular response to hypoxia in humans and mice. Methods and Results …
on the pulmonary vascular response to hypoxia in humans and mice. Methods and Results …
Heterozygous deficiency of hypoxia-inducible factor–2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
K Brusselmans, V Compernolle, M Tjwa… - The Journal of …, 2003 - Am Soc Clin Investig
Chronic hypoxia induces pulmonary vascular remodeling, leading to pulmonary
hypertension, right ventricular hypertrophy, and heart failure. Heterozygous deficiency of …
hypertension, right ventricular hypertrophy, and heart failure. Heterozygous deficiency of …
Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice
Heme oxygenase (HO) catalyzes the oxidation of heme to generate carbon monoxide (CO)
and bilirubin. CO increases cellular levels of cGMP, which regulates vascular tone and …
and bilirubin. CO increases cellular levels of cGMP, which regulates vascular tone and …