A framework to advance biomarker development in the diagnosis, outcome prediction, and treatment of traumatic brain injury

EA Wilde, IB Wanner, K Kenney, J Gill… - Journal of …, 2022 - liebertpub.com
Multi-modal biomarkers (eg, imaging, blood-based, physiological) of unique traumatic brain
injury (TBI) endophenotypes are necessary to guide the development of personalized and …

Thorough overview of ubiquitin C‐terminal hydrolase‐L1 and glial fibrillary acidic protein as tandem biomarkers recently cleared by US Food and Drug Administration …

KKW Wang, FH Kobeissy, Z Shakkour… - Acute Medicine & …, 2021 - Wiley Online Library
Traumatic brain injury (TBI) is a major cause of mortality and morbidity affecting all ages. It
remains to be a diagnostic and therapeutic challenge, in which, to date, there is no Food and …

Remote blood biomarkers of longitudinal cognitive outcomes in a population study

KB Rajan, NT Aggarwal, EA McAninch… - Annals of …, 2020 - Wiley Online Library
Objective The longitudinal association of the blood biomarkers total tau (t‐tau),
neurofilament light (Nf‐L), and glial fibrillary acidic protein (GFAP) with common sporadic …

Epidemiology of concussions in national collegiate athletic association (NCAA) sports: 2014/15-2018/19

A Chandran, AJ Boltz, SN Morris… - … American Journal of …, 2022 - journals.sagepub.com
Background: Updated epidemiology studies examining sports-related concussions (SRCs)
are critical in evaluating recent efforts aimed at reducing the incidence of SRCs in National …

Colloidal gold-based immunochromatographic biosensor for quantitative detection of S100B in serum samples

L Ye, L Xu, H Kuang, X Xu, C Xu - Nanoscale Horizons, 2023 - pubs.rsc.org
Traumatic brain injury has become a serious public health problem. Timely detection,
diagnosis and treatment of brain injury are closely related to the prognosis of patients, so …

Association of CSF and serum neurofilament light and glial fibrillary acidic protein, injury severity, and outcome in spinal cord injury

S Stukas, J Cooper, J Gill, N Fallah, MA Skinnider… - Neurology, 2023 - AAN Enterprises
Background and Objectives Traumatic spinal cord injury (SCI) is highly heterogeneous, and
tools to better delineate pathophysiology and recovery are needed. Our objective was to …

[HTML][HTML] The current state of traumatic brain injury biomarker measurement methods

AD Krausz, FK Korley, MA Burns - Biosensors, 2021 - mdpi.com
Traumatic brain injury (TBI) is associated with high rates of morbidity and mortality partially
due to the limited tools available for diagnosis and classification. Measuring panels of …

[HTML][HTML] Perspectives on primary blast injury of the brain: translational insights into non-inertial low-intensity blast injury

HR Siedhoff, S Chen, H Song, J Cui, I Cernak… - Frontiers in …, 2022 - frontiersin.org
Most traumatic brain injuries (TBIs) during military deployment or training are clinically “mild”
and frequently caused by non-impact blast exposures. Experimental models were …

[HTML][HTML] One-year prospective study of plasma biomarkers from CNS in patients with mild traumatic brain injury

GJB Clarke, T Skandsen, H Zetterberg… - Frontiers in …, 2021 - frontiersin.org
Objective: To investigate the longitudinal evolution of three blood biomarkers: neurofilament
light (NFL), glial fibrillary acidic protein (GFAP) and tau, in out-patients and hospitalized …

Serum tau, neurofilament light chain, glial fibrillary acidic protein, and ubiquitin carboxyl-terminal hydrolase L1 are associated with the chronic deterioration of …

RT Lange, S Lippa, TA Brickell, J Gill… - Journal of …, 2023 - liebertpub.com
The purpose of this study was to examine the association of serum tau, neurofilament light
chain (NFL), glial fibrillary acidic protein (GFAP), and ubiquitin carboxy-terminal hydrolase …