[HTML][HTML] Pathogenesis of autoimmune disease

DS Pisetsky - Nature Reviews Nephrology, 2023 - nature.com
Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …

[HTML][HTML] Therapeutic trials in adult FSGS: lessons learned and the road forward

AS De Vriese, JF Wetzels, RJ Glassock… - Nature reviews …, 2021 - nature.com
Focal segmental glomerulosclerosis (FSGS) is not a specific disease entity but a lesion that
primarily targets the podocyte. In a broad sense, the causes of the lesion can be divided into …

Ion channels and channelopathies in glomeruli

A Staruschenko, R Ma, O Palygin… - Physiological …, 2023 - journals.physiology.org
An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling

J Jansen, BT van den Berge, M van den Broek… - …, 2022 - journals.biologists.com
Nephrotic syndrome (NS) is characterized by severe proteinuria as a consequence of kidney
glomerular injury due to podocyte damage. In vitro models mimicking in vivo podocyte …

[HTML][HTML] Co-culture of glomerular endothelial cells and podocytes in a custom-designed glomerulus-on-a-chip model improves the filtration barrier integrity and affects …

DC 't Hart, D Yildiz, V Palacio-Castañeda, L Li… - Biosensors, 2023 - mdpi.com
Crosstalk between glomerular endothelial cells and glomerular epithelial cells (podocytes)
is increasingly becoming apparent as a crucial mechanism to maintain the integrity of the …

[HTML][HTML] Characterizing Glomerular Barrier Dysfunction with Patient-Derived Serum in Glomerulus-on-a-Chip Models: Unveiling New Insights into Glomerulonephritis

SY Kim, YY Choi, EJ Kwon, S Seo, WY Kim… - International Journal of …, 2024 - mdpi.com
Glomerulonephritis (GN) is characterized by podocyte injury or glomerular filtration
dysfunction, which results in proteinuria and eventual loss of kidney function. Progress in …

[HTML][HTML] Novel mouse strains to study circulating permeability factor (s) in primary focal segmental glomerulosclerosis

D den Braanker, R Maas, N Parr, J Deegens, B Smeets… - Plos one, 2022 - journals.plos.org
Recurrence of proteinuria after kidney transplantation in primary focal segmental
glomerulosclerosis (FSGS) is unpredictable. Several putative circulating permeability factors …

Current approaches to overcome recurrent focal segmental glomerulosclerosis after kidney transplantation

SB Ahmad, Y Peleg, W Ahn - Current opinion in nephrology and …, 2024 - journals.lww.com
Posttransplant recurrent FSGS can have a deleterious effect on allograft. Early detection of
disease recurrence with prompt treatment is optimal for clinical remission. Plasmapheresis …

[HTML][HTML] “Presumed” primary focal segmental glomerulosclerosis: a novel nuance for steroid therapy

RJ Glassock, FC Fervenza - Kidney International Reports, 2022 - kireports.org
Treatment of a light micro-scopic (LM) lesion of focal segmental glomerulosclerosis (FSGS)
discovered in a kidney biopsy specimen in a patient with proteinuria has been shrouded in …

[HTML][HTML] Gene association analysis to determine the causal relationship between immune-mediated inflammatory diseases and frozen shoulder

Y Zhou, X Yin, C Wang, D Yu - Medicine, 2024 - journals.lww.com
Multiple studies have indicated a potential correlation between immune-mediated
inflammatory diseases (IMIDs) and Frozen shoulder (FS). To explore the genetic causal …