Monocytes develop in the bone marrow and represent the primary type of mononuclear
phagocyte found in the blood. They were long thought of as a source for tissue …

During development and throughout adult life, macrophages derived from hematopoietic
progenitors are seeded throughout the body, initially in the absence of inflammatory and …

The skin represents the primary interface between the host and the environment. This organ
is also home to trillions of microorganisms that play an important role in tissue homeostasis …

Classical dendritic cells (cDCs) form a critical interface between innate and adaptive
immunity. As myeloid immune cell sentinels, cDCs are specialized in the sensing of …

The discovery of long noncoding RNAs (lncRNA) has provided a new perspective on gene
regulation in diverse biological contexts. lncRNAs are remarkably versatile molecules that …

The two major lineages of classical dendritic cells (cDCs) express and require either IRF8 or
IRF4 transcription factors for their development and function. IRF8-dependent cDCs promote …

While conventional pathogenic protists have been extensively studied, there is an
underappreciated constitutive protist microbiota that is an integral part of the vertebrate …

The skin is a complex and dynamic ecosystem that is inhabited by many microorganisms.
Recent evidence highlights the profound reliance of the skin immune system on its resident …

Our understanding of conventional dendritic cell (cDC) development and the functional
specializations of distinct subsets in the peripheral tissues has increased greatly in recent …

Immune cells were traditionally considered as major pro-inflammatory contributors. Recent
advances in molecular immunology prove that immune cell lineages are composed of …