The cross-talk between STAT1/STAT3 and ROS up-regulates PD-L1 and promotes the release of pro-inflammatory/immune suppressive cytokines in primary …
MA Romeo, MSG Montani, R Benedetti, L Giambelli… - Virus Research, 2021 - Elsevier
Programmed death ligand 1 (PD-L1) up-regulation on antigen presenting cells induces T
cell dysfunction, strongly impairing immune response. Human Herpesviruses (HHV) 6B is a …
cell dysfunction, strongly impairing immune response. Human Herpesviruses (HHV) 6B is a …
[HTML][HTML] TLR4 and pSTAT3 Expression on Circulating Tumor Cells (CTCs) and Immune Cells in the Peripheral Blood of Breast Cancer Patients: Prognostic …
MA Papadaki, A Monastirioti, CA Apostolopoulou… - Cancers, 2022 - mdpi.com
Simple Summary Toll-like receptor 4 (TLR4) and phosphorylated signal transducer and
activator of transcription protein 3 (pSTAT3) play a prominent role in cancer inflammation …
activator of transcription protein 3 (pSTAT3) play a prominent role in cancer inflammation …
Nature's Arsenal: Harnessing the Capacity of Phytochemicals to Enhance Immune Checkpoint Inhibitor Therapy of Cancers: An Especial Attention to Brain …
AR Afshari, M Sanati, SS Ahmadi, P Kesharwani… - Cancer Letters, 2024 - Elsevier
Brain cancers, particularly glioblastoma multiforme (GBM), are challenging health issues
with frequent unmet aspects. Today, discovering safe and effective therapeutic modalities for …
with frequent unmet aspects. Today, discovering safe and effective therapeutic modalities for …
B7H6 silencing increases chemosensitivity to dacarbazine and suppresses cell survival and migration in cutaneous melanoma
Cutaneous melanoma (CM) is a highly metastatic cancer whose incidence rate is
heightening worldwide. B7H6, as one of the co-stimulatory ligands of the B7 family, is …
heightening worldwide. B7H6, as one of the co-stimulatory ligands of the B7 family, is …
[HTML][HTML] Targeting STAT3 and STAT5 in Cancer
Insights into the mutational landscape of the human cancer genome coding regions defined
about 140 distinct cancer driver genes in 2013, which approximately doubled to 300 in 2018 …
about 140 distinct cancer driver genes in 2013, which approximately doubled to 300 in 2018 …
[HTML][HTML] Efficient polymeric nanoparticles for RNAi in macrophage reveal complex effects on polarization markers upon knockdown of STAT3/STAT6
M Walther, R Jenke, A Aigner, A Ewe - European Journal of Pharmaceutics …, 2024 - Elsevier
Tumor associated macrophages (TAMs) are the most abundant immune cell type in the
tissue microenvironment, affecting tumor progression, metastasis and therapeutic response …
tissue microenvironment, affecting tumor progression, metastasis and therapeutic response …
[HTML][HTML] Mechanism of Action of Melatonin as a Potential Adjuvant Therapy in Inflammatory Bowel Disease and Colorectal Cancer
Inflammatory bowel disease (IBD), a continuum of chronic inflammatory diseases, is tightly
associated with immune system dysregulation and dysbiosis, leading to inflammation in the …
associated with immune system dysregulation and dysbiosis, leading to inflammation in the …
[HTML][HTML] RNAi mediated silencing of STAT3/PD-L1 in tumor-associated immune cells induces robust anti-tumor effects in immunotherapy resistant tumors
S Ganesh, MJ Kim, J Lee, X Feng, K Ule, A Mahan… - Molecular Therapy, 2024 - cell.com
Malignant tumors are often associated with an immunosuppressive tumor microenvironment
(TME), rendering most of them resistant to standard-of-care immune checkpoint inhibitors …
(TME), rendering most of them resistant to standard-of-care immune checkpoint inhibitors …
Potential value and mechanism of Rosa roxburghii tratt juice on pro-inflammatory responses in peripheral blood of patients with arsenic poisoning
L Dong, S Xia, B Sun, L Ma, X Chen… - Human & …, 2022 - journals.sagepub.com
Increasing evidence supports the role of arsenic in dysregulated immune and inflammation
responses, while, safe and effective treatments have not been fully examined. Rosa …
responses, while, safe and effective treatments have not been fully examined. Rosa …
[HTML][HTML] Coagulation Protease-Driven Cancer Immune Evasion: Potential Targets for Cancer Immunotherapy
S Paul, T Mukherjee, K Das - Cancers, 2024 - mdpi.com
Simple Summary Blood coagulation and cancer are intrinsically related; hyper-thrombotic
complications are often observed in certain types of tumors. On the other hand, coagulation …
complications are often observed in certain types of tumors. On the other hand, coagulation …