HLA-DRB1⁎ 15 and cerebrospinal-fluid-specific oligoclonal immunoglobulin G bands lower age at attainment of important disease milestones in multiple sclerosis
K Imrell, E Greiner, J Hillert, T Masterman - Journal of neuroimmunology, 2009 - Elsevier
Abstract Carriage of HLA-DRB1⁎ 15 is the most important genetic risk factor in multiple
sclerosis (MS), while CSF-specific oligoclonal immunoglobulin G bands (OCB) constitute the …
sclerosis (MS), while CSF-specific oligoclonal immunoglobulin G bands (OCB) constitute the …
Implications for health and disease in the genetic signature of the Ashkenazi Jewish population
Background Relatively small, reproductively isolated populations with reduced genetic
diversity may have advantages for genomewide association mapping in disease genetics …
diversity may have advantages for genomewide association mapping in disease genetics …
Pediatric multiple sclerosis: genes, environment, and a comprehensive therapeutic approach
R Cappa, L Theroux, JN Brenton - Pediatric neurology, 2017 - Elsevier
Background Pediatric multiple sclerosis is an increasingly recognized and studied disorder
that accounts for 3% to 10% of all patients with multiple sclerosis. The risk for pediatric …
that accounts for 3% to 10% of all patients with multiple sclerosis. The risk for pediatric …
Microarray-Based Detection of CYP1A1, CYP2C9, CYP2C19, CYP2D6, GSTT1, GSTM1, MTHFR, MTRR, NQO1, NAT2, HLA-DQA1, and AB0 Allele …
O Gra, O Mityaeva, I Berdichevets… - Genetic testing and …, 2010 - liebertpub.com
Xenobiotic-metabolizing genes (eg, Cytochromes P450, GST, NAT2, and NQO1), folate
metabolism genes (eg, MTHFR and MTRR), and major histocompatibility complex genes …
metabolism genes (eg, MTHFR and MTRR), and major histocompatibility complex genes …
HLA Associations of Intrathecal IgG Production against Specific Viruses in Multiple Sclerosis
S Neidhart, B Vlad, M Hilty, KA Högelin… - Annals of …, 2024 - Wiley Online Library
Objective Specific human leucocyte antigen (HLA) alleles are not only associated with
higher risk to develop multiple sclerosis (MS) and other autoimmune diseases, but also with …
higher risk to develop multiple sclerosis (MS) and other autoimmune diseases, but also with …
Peptide mimotopes alter T cell function in cancer and autoimmunity
JE Slansky, M Nakayama - Seminars in immunology, 2020 - Elsevier
T cells recognize and respond to self antigens in both cancer and autoimmunity. One
strategy to influence this response is to incorporate amino acid substitutions into these T cell …
strategy to influence this response is to incorporate amino acid substitutions into these T cell …
Epigenetics in multiple sclerosis
VSF Chan - Epigenetics in allergy and autoimmunity, 2020 - Springer
Multiple sclerosis (MS) is an aggravating autoimmune disease that cripples young patients
slowly with physical, sensory and cognitive deficits. The break of self-tolerance to neuronal …
slowly with physical, sensory and cognitive deficits. The break of self-tolerance to neuronal …
Clinical and transcriptional recovery profiles in pediatric and adult multiple sclerosis patients
S Menascu, Y Khavkin, R Zilkha‐Falb… - Annals of Clinical …, 2021 - Wiley Online Library
Objective To determine whether pediatric‐onset multiple sclerosis (POMS) and adults‐onset
multiple sclerosis (AOMS) patients are different in initial disease severity and recovery and …
multiple sclerosis (AOMS) patients are different in initial disease severity and recovery and …
Multiple sclerosis associates with LILRA3 deletion in Spanish patients
D Ordonez, AJ Sanchez, JE Martinez-Rodriguez… - Genes & …, 2009 - nature.com
The genetic susceptibility to multiple sclerosis (MS) is only partially explained, and it shows
geographic variations. We analyse here two series of Spanish patients and healthy controls …
geographic variations. We analyse here two series of Spanish patients and healthy controls …
Multiple sclerosis in Colombia and other Latin American countries
The spectrum of multiple sclerosis (MS) in Latin America is characterized by geographic and
racial/genetic particularities. In this review we describe major studies of MS epidemiology …
racial/genetic particularities. In this review we describe major studies of MS epidemiology …