Tumour necrosis factor (TNF)‐mediated signalling plays a key role in inflammatory and
neurodegenerative processes leading to the development of multiple sclerosis (MS). Recent …

BACKGROUND: Recently a high-resolution HLA and SNP map was defined and the
analysis provided informative tag SNPs that capture much of the common variation in the …

Genetic susceptibility to multiple sclerosis (MS) is associated with genes of the major
histocompatibility complex, particularly with the HLA DRB1* 1501-DQA1* 0102-DQB1* 0602 …

Although autoimmune diseases by definition imply adaptive immune system pathologies,
growing evidence points to the relevance of innate receptors in modulating the initiation and …

BACKGROUND: Multiple sclerosis (MS) is a demyelinating inflammatory disease of the
central nervous system originated by a complex interplay of environmental and genetic …

Recently published studies have implicated the deletion polymorphism in LILRA3 gene, as
being associated with multiple sclerosis (MS). A total of 309 patients diagnosed with MS and …

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease that affects the
central nervous system (CNS) 1 and is thought to be autoimmune in nature. It is …

Objective Clinical response to immunomodulatory therapies in multiple sclerosis (MS) is
variable among patients. Currently, there are no validated biomarkers of clinical response to …

This meta-analysis explores association of HLA-DRB1 alleles with MS risk in the Middle-
east North Africa (MENA) countries. Divided into two groups of alleles (10 studies, 899 …

Background and aim: Multiple sclerosis (MS) is a chronic inflammatory disease that involves
central nervous system, and is generally associated with demyelination and axonal lesion …