BACKGROUND: Practice guidelines reflect published literature. Because of the ever
changing literature base, it is necessary to update and revise guideline recommendations …

THE purpose of this review is to evaluate recent developments in our understanding of the
inflammatory response to cardiac surgery. Scientific knowledge in this field is continually …

Platelets are the smallest of the blood cells and are known to be activated during
cardiopulmonary bypass. They play a role in many associated complications. Both …

Transfusion of allogeneic blood products during and after cardiac operations is common.
When the degree of anemia and the consequent decrease in oxygen delivery lead to organ …

Background Concerns regarding the safety of transfused blood have generated
considerable enthusiasm for the use of technologies intended to reduce the use of …

IMPLICATIONS: This trial of plateletpheresis in reoperative coronary artery surgery was
performed to assess its effect on allogeneic blood product transfusion. Routine …

Platelet dysfunction is the most common cause of nonsurgical bleeding after
cardiopulmonary bypass (CPB). We hypothesized that reinfusion of a therapeutic quantity of …

Objective: Our purpose was to determine whether intraoperative platelet-rich
plasmapheresis in cardiac surgery is effective in reducing the proportion of patients exposed …

Perioperative coagulopathy and bleeding are common complications in cardiovascular
surgery with cardiopulmonary bypass and result in an increased rate of allogeneic blood …

Apheresis has developed into a common therapeutic modality. The evidence for the clinical
benefit of apheresis, however, is generally from uncontrolled and nonrandomized trials …