Mitochondria account for essential cellular pathways, from ATP production to nucleotide
metabolism, and their deficits lead to neurological disorders and contribute to the onset of …

Neuroblastoma is believed to arise from sympathetic neuroblast precursors that fail to
engage the neuronal differentiation programme, but instead become locked in a pro …

Central nervous system (CNS) damage is usually irreversible owing to the limited
regenerative capability of neurons. Following CNS injury, astrocytes are reactively activated …

Direct neuronal reprogramming, the process whereby a terminally differentiated cell is
converted into an induced neuron without traversing a pluripotent state, has tremendous …

Pioneer factors are a subclass of transcription factors that can bind and initiate opening of
silent chromatin regions. Pioneer factors subsequently regulate lineage-specific genes and …

Schizophrenia (SZ) is a common psychiatric neurodevelopmental disorder with a complex
genetic architecture. Genome-wide association studies indicate the involvement of several …

Neuroblastoma originates from developing neural crest and can interconvert between the
mesenchymal (MES) and adrenergic (ADRN) states, each of which are controlled by …

ABSTRACT The Company of Biologists' 2022 workshop on 'Cell State Transitions:
Approaches, Experimental Systems and Models' brought together an international and …

Abstract HNRNPA2B1 and HNRNPR stabilize ASCL1 mRNA in neuroblastoma, but whether
their regulatory effects depend on m6A modification and whether their function involves …

INTRODUCTION: Despite a two-fold increased risk, individuals of African ancestry have
been significantly underrepresented in Alzheimers Disease (AD) genomics efforts …